Xenotherapeutics Corporation

Alexis Bio, Inc.

Lobbyassist, LLC

Travis Brown

Paul W Holzer

Elizabeth J Chang

Jon Adkins

Rodney L Monroy

Kaitlyn Rogers

Lukasz R Tomicki

Larry J Stendebach

Andrey Ptitsyn

A method for predictive engineering of a sample derived from a genetically optimized non-human donor suitable for xenotransplantation into a human having improved quality or performance is provided. The method includes constructing a training data set from a series of libraries, wherein at least one library in the series of libraries comprises genomic, proteomic, and research data specific to non-humans. The method includes developing a predictive machine learning model based on the constructed training data set. The method includes utilizing the predictive machine learning model to obtain a predicted quality or performance of a plurality of sequences for a candidate sample from the non-human donor specific to a human patient or patient population. The method includes selecting a subset of sequences for evaluation from the plurality of sequences based on the predicted quality or performance. The method includes designing candidate samples derived from the non-human donor using the selected subset of sequences. The method includes measuring a respective in silico performance of each designed candidate sample. The method includes selecting a designed candidate sample for manufacture based on the respective in silico performance of each designed candidate sample.

Selection and monitoring methods for xenotransplantation

A method for managing legislative information. in operation, legislative information, including text comprising legislative bills, is collected via an electronic search of at least one website. The text of the bills is then parsed into predefined categories. The text thus parsed is stored in a database. A search, using one of the predefined categories as search criteria, is then performed to select a subset of the bills meeting the search criteria. Information, related to the subset of the bills, is then transmitted to a requesting entity via an electronic communication.

System and method for managing legislative information

Growing community of inventors

Columbia, MO, United States of America

Travis Brown