Massachusetts Institute of Technology

The Charles Stark Draper Laboratory, Inc.

Northeastern University

Transon Van Nguyen

Jeffrey T Borenstein

Jonathan Robert Coppeta

Mark Joseph Mescher

Joseph D Cuiffi

Abigail June Spencer

Samuel Walker Inman

David L Trumper

Linda G Griffith

Rebecca Lyn Carrier

Collin D J Edington

Emily C Suter

Joseph Dennis Cuiffi

A device for controlling apical flow to a cell culture includes an apical insert that defines at least one inlet channel extending from an inlet port to an apical feed port and at least one outlet channel extending from an apical effluent port to an outlet port. The apical insert includes a projecting portion configured to extend into a cell culture insert to a depth that is less than a depth of the cell culture insert, and a contact surface configured to maintain a spatial relationship between the projecting portion and the cell culture insert.

Device for controlled apical flow in cell culture inserts

The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the organ systems are fluidically connected with a constant-volume pump.

Modular platform for multi-tissue integrated cell culture

Growing community of inventors

San Diego, CA, United States of America

Transon Van Nguyen