Edwards Lifesciences Corporation

Other

Tram Ngoc Nguyen

Michael G Valdez

Sergio Delgado

Dustin P Armer

Eason Michael Abbott

Michael D Franklin

Stanton J Rowe

Son V Nguyen

Russell Thomas Joseph

Dinesh L Sirimanne

Vivian Tran

Hien Tran Ngo

Abhijeet Joshi

Charles L Bowman

Mark M Dehdashtian

Bryan A Janish

Walter Lee

Timothy C Ulrich

Gilbert S Leung

Teodoro S Jimenez

Tamir S Levi

David Maimon

Ziv Yohanan

Alexander H Cooper

Tri D Tran

Darshin S Patel

Sean Chow

Teodoro S Jimenez, Jr

Evan T Schwartz

Yuanlong Du

Jocelyn Chau

Kurt Kelly Reed

Jason Seng-Che Lam

Alyssa Joy Gross

Ngoc Huong Thi Nguyen

Hannah Reed Bettencourt

Corey Maurice Marshall

Systems, assemblies, and methods for treating valve regurgitation and other valve problems are described. Prosthetic valves can have integrated coverings or flanges. Prosthetic valves can have a flange attached to the inflow end of the annular frame and designed to extend outwardly therefrom. Docking devices can be used to repair or reshape native heart valves and to secure prosthetic heart valves at a specific location and position relative to a native heart valve. Delivery systems can be used to deploy a docking device into the heart, including a lubricous sleeve in the delivery system. Packaging and storage systems suitable for the delivery systems are described.

Systems, devices, and methods for treating heart valves

Stent

Described herein are systems and methods from delivering prosthetic devices, such as prosthetic heart valves, through the body and into the heart for implantation therein. The prosthetic devices delivered with the delivery systems disclosed herein are, for example, radially expandable from a radially compressed state mounted on the delivery system to a radially expanded state for implantation using an inflatable balloon of the delivery system. Exemplary delivery routes through the body and into the heart include transfemoral routes, transapical routes, and transaortic routes, among others.

Delivery systems for prosthetic heart valve

An expandable docking station frame includes a waist portion, a sealing portion connected to the waist portion, and a retaining portion connected to the sealing portion. The sealing portion is expandable radially outward of the waist portion to provide a seal against a first location of an inner surface of a circulatory system at a deployed position over a range of sizes of expansion. The retaining portion is expandable radially outward to engage a second location of the inner surface of the circulatory system at the deployed position, to retain the docking station at the deployed position in the circulatory system. When the expandable docking station frame is in an expanded and unconstrained state, the sealing portion and the retaining portion are joined by a concave profile portion radially inward of each of a first outermost diameter of the sealing portion and a second outermost diameter of the retaining portion.

Devices and systems for docking a heart valve

An expandable stent for implantation in a right ventricular outflow tract includes a frame having a waist portion that expands to a deployed size having a first diameter, first and second sealing portions extending in opposite directions from the waist portion and expanding radially outward of the waist portion. The first and second sealing portions are sized to seal against first and second portions of the inner surface of the right ventricular outflow tract at the deployed position over a range of sizes of expansion larger than the first diameter. A band is secured to the waist portion of the frame, restricting expansion of the waist portion substantially beyond the first diameter, such that the waist portion is configured to be spaced apart from the inner surface of the right ventricular outflow tract at the deployed position.

In a method of installing an expandable stent in a right ventricular outflow tract, a frame of the expandable stent is positioned at a deployed position in the right ventricular outflow tract, the frame including a waist portion, and first and second opposed sealing portions extending from the waist portion. The frame is expanded such that the waist portion expands to a first diameter, the first sealing portion expands to a second diameter larger than the first diameter and into contact with a first portion of an inner surface of the right ventricular outflow tract, and the second sealing portion expands to a third diameter larger than the first diameter and into contact with a second portion of the inner surface of the right ventricular outflow tract, wherein the waist portion is spaced apart from the inner surface of the right ventricular outflow tract at the deployed position.

Methods for docking a heart valve

An expandable stent for implantation in a right ventricular outflow tract includes a frame having a plurality of struts that define a repeating pattern of cells. The repeating pattern of cells comprises a column of exactly three generally diamond shaped cells positioned in end-to-end alignment, and a column of exactly two generally diamond shaped cells positioned in end-to-end alignment. The frame has a substantially hourglass shape with a narrow portion in between a proximal end portion and a distal end portion, wherein the proximal end portion and the distal end portion are configured to expand radially outward to contact a right ventricular outflow tract.

Expandable docking stations for docking an expandable valve can include a valve seat, one or more sealing portions, and/or one or more retaining portions. The valve seat can be unexpandable or substantially unexpandable beyond a deployed size. The one or more sealing portions can be connected to the valve seat and extend radially outward of the valve seat. The one or more sealing portions can be constructed to expand outward of the valve seat and provide a seal over a range of sizes. The one or more retaining portions can be connected to the one or more sealing portions. The one or more retaining portions are configured to retain the docking station at a deployed position.

An implantable prosthetic valve can include an annular frame comprising an inflow end and an outflow end and being radially collapsible and expandable between a radially collapsed configuration and a radially expanded configuration. A leaflet structure can be positioned within the frame and secured thereto. An annular sealing member can be positioned around an outer surface of the frame, wherein the sealing member has a periodic, undulating shape. An outer skirt can be positioned around an outer surface of the sealing member and secured to the frame.

Sealing member for prosthetic heart valve

Prosthetic valve embodiments are described herein that include a frame and a valve member mounted within the frame. The valve members can have a plurality of leaflets that are affixed to one another along their inflow edges, with articulating edges projecting from the inflow edges in the outflow direction. In an open configuration, the articulating edges can be collapsed radially inward by the forward flow of blood through the prosthetic valve, thereby creating a plurality of discrete flow areas between the frame and the inflow edges of the leaflets. In a closed configuration, the leaflets can be pushed radially outward by the reverse flow of blood, thereby closing the plurality of discrete flow areas.

Inverted leaflet prosthetic valve

Expandable docking stations for docking an expandable valve can include a valve seat, one or more sealing portions, and one or more retaining portions. The valve seat can be unexpandable or substantially unexpandable beyond a deployed size. The one or more sealing portions are connected to the valve seat and extend radially outward of the valve seat. The one or more sealing portions are constructed to expand outward of the valve seat and provide a seal over a range of sizes. The one or more retaining portions are connected to the one or more sealing portions. The one or more retaining portions are configured to retain the docking station at a deployed position.

Growing community of inventors

Santa Ana, CA, United States of America

Tram Ngoc Nguyen