Molecular Bioquest, Inc.

Bioquest, Inc.

Binax Nh, Inc.

Tracy J Hamilton

Mark S Chagnon

Michelle J Carter

John R Ferris

Barry L Fiore

Edwin A Rudd

Deborah A Kaplan

John Havelick, Jr

Maria A Gray

Stephen E Burkle

Kristin L Marzloff

Inorganic oxides of substantially uniform particle size distribution are prepared by contacting aqueous solutions of an inorganic salt and an inorganic base across a porous membrane wherein the membrane contains a plurality of pores which allows for precipitation of a substantially mono-disbursed size inorganic oxide particles on one side of the membrane and precipitation of a salt of the corresponding base on a second side of the membrane.

Preparation of sub 100 A magnetic particles and magnetic molecular

Novel N-RES agents for use in vitro and in vivo medical and biological applications, such as, for example MRI and/or intravenous administration of pharmaceutical agents are described. The novel N-RES agents are prepared by coating inorganic core particles with a poly(acrylic acid)--poly(alkylene ether) graft copolymer. The resulting polymer-coated inorganic particle cores are useful as imaging agents, therapeutic agents or carriers having increased circulation time due to decrease uptake or recognition by the RES.

Preparation and use of novel injectable RES avoiding inorganic particles

A liposome composition which comprises a substantially uniform sized inorganic core coated with an amphipathic organic compound and further coated with a second amphipathic vesicle forming lipid. Also disclosed are novel phenyl lipid compounds which serve as the amphipathic vesicle forming lipid and methods are described for delivering a drug for slow release into the blood stream, and for targeting a selected tissue or cells with the inorganic core liposome compositions.

Solid care therapeutic compositions and methods for making same

Subdomain metal or metal oxide particles covalently coupled to chemically reactive organic moieties and subsequently reacted together to form biodegradable magnetic microclusters are disclosed. The magnetic microcluster can be used as contrast agents in NMR imaging for the production of images suitable for use in diagnosis, for in vivo delivery and targeting of drugs, as in vivo, biodegradable agents for the sequestering of free metal ions in the treatment of metal driven disease.

Biodegradable magnetic microclusters and methods for making them

Biodegradable magnetic microcluster comprising non-magnetic metal or

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Hudson, NH, United States of America

Tracy J Hamilton