Merck + Co., Inc.

Tracy Huening

Zhijian Lu

James R Tata

Subharekha Raghavan

Thomas A Rano

Yuan Cheng

David Askin

Kevin Tyler Chapman

Richard John Varsolona

Nancy J Kevin

Joseph Leslie Duffy

Mark G Charest

Fengqi Zhang

R Scott Hoerrner

Joseph D Armstrong, Iii

Brian Anthony Kirk

Robert M Purick

Fred Fleitz

Daniel E Petrillo

&ggr;-Hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamide compounds are inhibitors of HIV protease and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. These compounds are effective against HIV viral mutants which are resistant to HIV protease inhibitors currently used for treating AIDS and HIV infection.

Gamma-hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamides and uses thereof

Certain &agr;-hydroxy-&ggr;-&lsqb;&lsqb;(carbocyclic- or heterocyclic-substituted)amino&rsqb;carbonyl&rsqb;alkanamide derivatives are described as inhibitors of HIV protease and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. These compounds are effective against HIV viral mutants which are resistant to HIV protease inhibitors currently used for treating AIDS and HIV infection.

Alpha-hydroxy-gamma-&lsqb;&lsqb;(carbocyclic-or heterocyclic-substituted)amino&rsqb;carbonyl&rsqb;alkanamide derivatives and uses thereof

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Madison, NJ, United States of America

Tracy Huening