Otsuka Pharmaceutical Company, Limited

Hyogo College of Medicine

Toyoki Mori

Michiaki Tominaga

Muneaki Kurimura

Fujio Tabusa

Isao Takemura

Goro Miyakoda

Hiroshi Yamashita

Masatoshi Chihiro

Takayuki Matsuzaki

Kazuyoshi Kitano

Hisashi Nagamoto

Shinobu Sueyoshi

Tomoichi Shinohara

Yoshihisa Tanada

Hidenori Ogawa

Yoichi Yabuuchi

Kazumi Kondo

Kaoru Abe

Minoru Uchida

Kenji Nakaya

Keizo Kan

Takahito Yamauchi

Kazuyoshi Nagami

Seiji Morita

Yukihisa Ono

Kenji Tsujimae

Toshiyuki Onogawa

Tatsuya Yamashita

Takashi Imaizumi

Ayako Hashimoto

Hidenorii Ogawa

Yoshihisa Yamada

Shigeki Nakamura

Yoshitaka Yamamura

Kaori Murata

Fusako Iwata

Youichi Yabuuchi

Hideji Nakamura

Keiko Oga

The present invention provides a pharmaceutical composition for promoting angiogenesis, which has an angiogenesis promoting action even in a vascular culturing system without effect of microcirculation. A pharmaceutical composition for promoting angiogenesis of the present invention comprises at least one compound selected from a group consisting of a piperidine compound represented by the general formula (1) or salts thereof: (wherein R represents a benzoyl group which may have, as substituents on the phenyl ring, 1 to 3 groups selected from a group consisting of an amino group, which may have a lower alkanoyl group, and a lower alkyl group; Rrepresents a hydrogen atom or a lower alkyl group; and Rrepresents a phenyl lower alkyl group). 

Pharmaceutical composition for promoting angiogenesis

The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: [wherein Ris a phenyl group which may have a lower alkoxy group(s) as a substituent(s) on the phenyl ring, and Ris a group represented by the following general formula: (wherein R's, which may be the same or different, are each a carboxyl group, a lower alkoxy group or the like) or the like] and salts thereof.

Agent for inhibition of cytokine production and agent for inhibition of cell adhesion

The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula:

Thiazole derivative

Benzazepine derivatives with vasopressin agonistic activity

TNF-.alpha.inhibitor

Agent for prophylaxis or treatment of cataract

Growing community of inventors

Naruto, Japan

Toyoki Mori