Shionogi Company Limited

Toyohiko Takeda

Teruo Sakamoto

Yusuke Suzuki

Yoshio Hamashima

Kyozo Kawata

Kyoji Minami

Kinzaburo Noda

Masanori Tujikawa

Yoshihiro Furuya

Sadao Kawai

Tadatsugu Tanino

Toshiro Fujii

Toshihiro Ogura

Hayao Inoue

Yoshitaka Tomoda

Yoshiyuki Endo

Koji Sato

Hiroshi Kato

The centrifugal fluidizing granulator for powder coating granulation has a sensor for detecting changes of viscosity of the growing particles by means of a load cell or a displacement detector; and output signal of the sensor is compared with the data stored in a memory contained in a control unit which determines whether the growing particles are in their wetted state or dried state. The control unit controls the spraying of the liquid and the dispersion of the guest powder based on the result of the comparison.

Centrifugal fluidizing granulator for powder coating granulation

A method for molding powder under compression by use of a compression molding machine including a horizontally supported turntable provided with bores vertically extending therethrough, and upper pressure rods and lower pressure rods respectively positioned above and below the respective bores, the upper end portion of each lower pressure rod being fitted in the corresponding bore. The method includes subjecting powder contained in each bore to preliminary compression by dropping the corresponding upper pressure rod into the bore by gravity before the compression molding operation.

Method for molding powder under compression

A rotary powder compression machine with a horizontal turntable for compressing powder placed into a compression bore between an upper and a lower compression rods. An ultrasonic sensor monitors the amount of powder deposited upstream of the open feed shoe in the rotation direction of the turn-table.

Rotary powder compression molding machine

Sustained-release preparations essentially consisting of 1 part by weight of a water-soluble active ingredient and 1 to 10 parts by weight of two or more fats where the melting point is different in one from others, being capable of releasing active ingredients at a constant rate for a long-period of time, and being manufactured easily and economically.

Sustained-release preparations and the process thereof

An antibacterial, 7.beta.-[(Z)-2-(2-aminothiazol-4-yl)-4-carboxybut-2-enoylamino]-3-cephem-4 -carboxylic acid is stable in a (di or tri)-hydrate crystal form. A pharmacologically effective amount of this hydrate is filled in a gelatin hard capsule and sealed by a band of gelatin to make a stable composition for clinical use after storage for a long time.

Gelatin hard capsule containing crystalline hydrate of oral cephalosporin

Method for preparing crystalline hydrate of oral celphalosporin and its

Sustained-release formulations which can release a water-soluble active ingredient or ingredients at the zero-order over a long period of time, comprising:

Sustained-release formulation and production thereof

An antibacterial, 7.beta.-[(Z)-2-(2-aminothiazol-4-yl)-4-carboxybut-2-enoylamino]-3-cephem-4 -carboxylic acid is stable in a (di or tri)-hydrate crystal form. A pharmacologically effective amount of this hydrate is filled in a gelatin hard capsule sealed by a band of gelatin to make a stable composition for clinical use after storage for a long time.

Crystalline hydrate of oral cephalosporin and its composition

Highly effective and orally administrable sustained-release preparation of an antihypertensive agent, pinacidil (N'-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine) comprising a rapid-release and a slow-release component at a ratio of about 7:3 to about 1:9 by pinacidil weight.

Sustained-release preparation of pinacidil

Highly potent long-acting formulation of cefaclor for treating bacterial infections in human or animals, comprising a rapid-release and a slow-release component at a ratio of about 3:7 to about 5:5 by potency of cefaclor, convenient for administration or carrying about.

Growing community of inventors

Hyogo, Japan

Toyohiko Takeda