Affibody Ab

General Electric Company

Tove Eriksson

Rong Zhang

Andreas Jonsson

Fredrik Nilsson

Mikaela Friedman

Stefan Stahl

Stefan Ståhl

Elin Gunneriusson

Fredrik Frejd

Christofer Lendel

Nina Herne

Paul Schaffer

Torbjörn Gräslund

Anders Erik Jarstad

Thomas Bergman

Jörgen Carlsson

Jingjing Li

This invention relates to polypeptides which bind to EGFR family receptors and to applications of those polypeptides in medicine, veterinary medicine, diagnosis, diagnostics, and imaging.

Polypeptides

This invention relates to polypeptides which bind to EGFR family receptors and to applications of those polypeptides in medicine, veterinary medicine, diagnosis diagnostics and imaging.

This invention relates to polypeptides which bind to IGF-1R and to applications of those polypeptides in medicine, veterinary medicine, diagnostics and imaging.

IGF-1R binding polypeptides and their use

A polypeptide is provided, which has a binding affinity for HER2 and which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having from 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, as well as expression vector and host cell for expressing the nucleic acid, are also provided. Also provided is the use of such a polypeptide as a medicament, and as a targeting agent for directing substances conjugated thereto to cells overexpressing HER2. Methods, and kits for performing the methods, are also provided, which methods and kits rely on the binding of the polypeptide to HER2.

Polypeptides having binding affinity for HER2

Growing community of inventors

Nacka, Sweden

Tove Eriksson