Beta-o2 Technologies Ltd.

Tel Aviv University

Glusense Ltd.

Tova Neufeld

Avi Rotem

Uriel Barkai

Yehezkel Bremer

Yosi Shacham-Diamand

Judith Rishpon

Rachela Popovtzer

Sefi Vernick

Yossi Gross

Tehila Hyman

Zohar Gendler

Ben-Tsion Williger

Dimitry Azarov

Shirley Giorini-Silfen

A system is provided, including a plurality of donor cells and a first alginate structure that encapsulates the plurality of donor cells. The first alginate structure has a guluronic acid concentration of between 64% and 74%. The system additionally includes a second alginate structure that surrounds the first alginate structure, the second alginate structure having a mannuronic acid concentration of between 52% and 60%. A selectively-permeable membrane is coupled at least in part to the second alginate structure. Other embodiments are also described.

Multiple-layer immune barrier for donor cells

Apparatus is provided, including a plurality of islets, and a hydrogel configured to macroencapsulate the plurality of islets. The hydrogel is implantable in a subcapsular space () of a kidney () of a subject and is shaped to define a planar configuration. Other applications are also described.

Optimization of alginate encapsulation of islets for transplantation

A method of detecting cancer cells is disclosed. The method comprises (a) contacting the cell which is suspicious of a cancerous or undifferentiated phenotype with 4-aminophenyl phosphate (p-APP) under conditions wherein alkaline phosphatase of the cell catalyzes a reaction of the cell with the p-APP, so as to generate a product capable of producing an electrical signal; and (b) measuring a level of the electrical signal, wherein a difference in a level of the electrical signal compared to a predetermined threshold is indicative of a cancer cell.

Electrochemical methods of detecting cancer with 4-aminophenyl phosphate

A method of detecting cancer cells is disclosed. The method comprises (a) contacting the cell with a substrate for an enzyme under conditions wherein the enzyme catalyzes a reaction of the cell with the substrate, so as to generate a product capable of producing an electrical signal; and (b) measuring a level of the electrical signal, wherein a difference in a level of the electrical signal compared to a predetermined threshold is indicative of a cancer cell. The method may be adapted for diagnosis, monitoring a cancer therapy, identifying agents capable of treating cancer and individually optimizing a cancer therapy.

Electrochemical methods of detecting colon cancer cells and use of same for diagnosing and monitoring treatment of the disease

A protein is provided, including a glucose binding site, cyan fluorescent protein (CFP), and yellow fluorescent protein (YFP). The protein is configured such that binding of glucose to the glucose binding site causes a reduction in a distance between the CFP and the YFP. Substance monitoring apparatus () is also provided, including a semi-permeable barrier (), adapted to be implanted in a body of a subject and to allow passage therethrough of a substance, while inhibiting passage therethrough of immune cells; and microorganisms (), disposed within the semi-permeable barrier () so as to produce a measurable response to a level of the substance. A sensor () is adapted to measure the measurable response and not to measure a response of any mammalian cells that may be disposed within the semi-permeable barrier ().

Implantable power sources and sensors

Growing community of inventors

Ariel, Israel

Tova Neufeld