Nitto Electric Industrial Co., Ltd.

Nitto-denko Corporation

Toa Eiyo Ltd.

Toa Eiyo Litd.

Toshiyuki Yoshikawa

Saburo Otsuka

Shoichi Tokuda

Katsuhiro Okada

Takashi Tsuji

Yuusuke Ito

Yasuyuki Sasaki

Kenji Furumori

Atsushi Hamada

Seishi Suzuki

Takamasa Kuroya

Tomoko Sudo

Yuko Ueda

Masao Nakagawa

Chieko Miura

Shinji Sugawara

Yuuseke Ito

Hiroshi Hatanaka

The present invention relates to a crosslinked gelatin support, in which a surface of a crosslinked gelatin is negatively charged and has a zeta potential in ethanol of from &#x2212;3 to &#x2212;50 mV, and a support for controlled release of a physiologically active substance, including: the crosslinked gelatin support; and a physiologically active substance adsorbed and retained on and/or inside the crosslinked gelatin support.

Crosslinked gelatin support and support for controlled release of physiologically active substance using the same

The present invention relates to a film base material for an adhesive skin patch, which includes an elastomer film unevenly having unevenness on at least one surface thereof, in which, in one unevenness in which the distance perpendicular to the surface of the elastomer film between the top of the unevenness and the bottom thereof is the longest among the plurality of unevenness, the distance is within the range of from 1 to 5 &#x3bc;m; in another unevenness in which the distance perpendicular to the surface of the elastomer film between the top of the unevenness and the bottom thereof is the shortest among the plurality of unevenness, the distance is within the range of from 0.1 to 0.9 &#x3bc;m; and the 10-point average roughness of the surface is within the range of from 0.5 &#x3bc;m to 3 &#x3bc;m, and which is decreased in glossy texture on the surface thereof and inconspicuous when it is applied to the skin or the like; and the adhesive skin patch including the film base material.

Film base material for adhesive skin patch and adhesive skin patch

A pressure-sensitive adhesive sheet comprising a plastic sheet having on one surface thereof a pressure-sensitive adhesive layer, wherein the plastic sheet has on at least one surface thereof a print layer having a thickness of 40 to 1,000 &mgr;m and containing 30 to 90% by weight based on the total weight of the print layer of an X-ray absorbing metal. The print pattern may be scales, grid lines, numbers, etc. singly or in combination. Information on individual subject or scales or grid lines pattern may be copied in a radiograph having an image of the inside of the subject body. This enables surgeons to determine the size of the inside of the subject body or position of target organ with ease.

Pressure-sensitive adhesive sheet for radiography

A pressure-sensitively adhering multilayer medicinal preparation comprises a pressure-sensitively adhering macromolecular substance layer and a polymer layer adjacent thereto and the drug and adjuvant incorporated in said preparation each can migrate from the layer of its original incorporation into the other, said adjuvant being capable of increasing absorption of the drug. In such preparation, the drug amount per unit volume can be increased.

Pressure-sensitively adhering composite medicinal preparation

A hydrophilic therapeutic material comprising a carrier and a drug-containing patching layer formed thereon directly or indirectly, wherein said patching layer comprises a copolymer of 5 to 75% by weight of an acrylic or methacrylic ester having an ether group in the molecule, 85 to 15% by weight of an alkyl acrylate or alkyl methacrylate and 10 to 50% by weight of a polar monomer copolymerizable therewith.

Hydrophilic therapeutic material

A process for obtaining a composite pharmaceutical preparation which comprises coating or laminating a composition comprising

Process for obtaining composite pharmaceutical preparation

A pharmaceutical preparation comprising a flexible backing and a base material provided thereon is described wherein the base material consists essentially of a polymer having a glass transition temperature of from -70.degree. C. to -10.degree. C. and exhibiting pressure-sensitivity at room temperature, and isosorbide dinitrate or pentaerythritol tetranitrate. This pharmaceutical preparation is applied to the skin, and permits the active ingredient to be absorbed through the skin into the body at a constant rate, and gradually over a long period of time.

Percutaneous absorption type pharmaceutical preparation of isosorbide

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Osaka, Japan

Toshiyuki Yoshikawa