Kirin Beer Kabushiki Kaisha

Toshiyuki Shimizu

Tetsuya Yoshino

Teruyuki Sakai

Yasunari Fujiwara

Kazuo Kubo

Tsuyoshi Nishitoba

Tatsushi Osawa

Atsushi Miwa

Hideko Murooka

Shinichiro Kato

Kazuki Kawakami

Masayoshi Nakoji

Kiyoshi Shimizu

Shinichi Ohyama

Kaname Kimura

Yoshiko Kobayashi

The present invention provides compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof: wherein X represents CH or N; Z represents &#x2014;O&#x2014;, &#x2014;NH&#x2014; or &#x2014;C(&#x2550;O)&#x2014;; R and R' represent a hydrogen atom, hydroxyl, a halogen atom, optionally substituted alkyl, optionally substituted alkenyl optionally substituted alkoxy, amino, aminocarbonyl, or an optionally substituted heterocyclic group; and A represents an optionally substituted specific carbocyclic or heterocyclic group. The compounds according to the present invention have excellent TGF&#x3b2; inhibitory activity.

Compound having TGF&#x3b2; inhibitory activity and medicinal composition containing the same

An objective of the present invention is to provide novel compounds which have inhibitory activity against autophosphorylation of an FGF receptor family and, when orally or intraveneously administered, can suppress the growth of cancer cells. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X represents CH or N; Z represents O or S; Q represents NR, CRR, carbonyl, O, S(&#x2550;O)m, wherein m is 0 to 2, or urea; Rto Reach independently represent H, OH, halogen, nitro, amino, alkyl, alkoxy or the like in which the alkyl and alkoxy groups are optionally substituted; Rrepresents H; Rto Reach independently represent H, halogen, alkyl, or alkoxy; and Rrepresents an optionally substituted carbocyclic or heterocyclic group.

Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors

Quinoline and quinazoline derivatives inhibiting platelet-derived growth

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Takasaki, Japan

Toshiyuki Shimizu