Chugai Seiyaku Kabushiki Kaisha

F. Hoffmann-La Roche Ag

Toshiyuki Mio

Hiroki Nishii

Lisha Wang

Masayuki Matsushita

Tadakatsu Hayase

Yoshito Nakanishi

Hirosato Ebiike

WeiLi Zhao

Masayuki Ohmori

Masami Kochi

Naoki Taka

Ikumi Hyodo

Kyoko Takami

Hiroshi Tanaka

Takeshi Murata

Satoshi Niizuma

Kihito Hada

Hatsuo Kawada

Hideaki Shimada

Sousuke Hara

Weili Zhao

The present invention relates to quinazolinedione derivatives represented by formula (I) or pharmaceutically acceptable salts thereof. 

Quinazolinedione derivative

A method for treating cancer that includes administering a pharmaceutically effective amount of a composition containing a compound represented by formula (I) or a pharmacologically acceptable salt thereof. In the formula, A represents a 5- to 10-membered heteroaryl group, or a Caryl group; Rand Rindependently represent H, OH, X, CN, NO, a Chaloalkyl group, a Calkyl group, or the like &#x3c;Rand Rtogether form a (substituted) 3- to 10-membered heterocyclyl group or a (substituted) 5- to 10-membered heteroaryl group&#x3e;; Rrepresents H, a Calkyl group, a Caryl group, a Calkyl group, or a Chaloalkyl group; and Rrepresents H, X, a Calkyl group, a Chaloalkyl group, OH, CN, NO, or the like. 

Aminopyrazole derivative

A compound represented by formula (I) or a pharmacologically acceptable salt thereof, which can inhibit a fibroblast growth factor receptor (FGFR) family kinase in cancer tissues. (In the formula, A represents a 5- to 10-membered heteroaryl group, or a Caryl group; Rand Rindependently represent H, OH, X, CN, NO, a Chaloalkyl group, a Calkyl group, or the like &#x3c;Rand Rtogether form a (substituted) 3- to 10-membered heterocyclyl group or a (substituted) 5- to 10-membered heteroaryl group&#x3e;; Rrepresents H, a Calkyl group, a Caryl group, a Calkyl group, or a Chaloalkyl group; and Rrepresents H, X, a Calkyl group, a Chaloalkyl group, OH, CN, NO, or the like.) 

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Kanagawa, Japan

Toshiyuki Mio