Hisamitsu Pharmaceutical Company, Inc.

Toshiyuki Matsudo

Seiji Tokumoto

Tetsuji Kuwahara

Shinpei Nishimura

Takito Shima

Kenji Ishigaki

Kumi Morimoto

Eiji Hashimoto

Toru Kobayashi

Takuya Umemoto

The present invention provides a system for manufacturing a therapeutic microneedle configured to regulate an air environment within a coating chamber for manufacturing a therapeutic microneedle by coating a microneedle with a coating liquid containing a drug, the system for manufacturing a therapeutic microneedle comprising an air compressor, a humidity regulator configured to regulate humidity of air supplied from the air compressor, and an air filter configured to eliminate microorganisms from air to be supplied to the inside of the coating chamber.

System for manufacturing microneedle preparation, and air-conditioning method

A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.

Method for producing microneedle device

A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains an adhesive base and an antioxidant containing a sulfur atom in its molecule.

Patch

The present invention provides a method of coating microneedles by which the microneedles mounted on a microneedle device are coated accurately and easily in a mass-producible manner. In this method, a microneedle device () with a plurality of microneedles () is mounted on a table (), while a mask plate () with a plurality of apertures () is fixed to a frame member (), and a coating solution () is drawn in the direction of arrow A on the mask plate () using a spatula () to fill the apertures () with the coating solution. The microneedles () are inserted in the apertures () before or after the filling of the apertures () with the coating solution () to coat the microneedles ().

Method of coating microneedle

It is intended to provide a transdermal drug administration apparatus having microneedles, which is capable of piercing the skin by a simple procedure in the transdermal administration of a biologically active substance (drug) and allows rapid absorption of the biologically active substance. The present apparatus comprises a microneedle device () comprising a microneedle substrate () having a plurality of microneedles () capable of piercing the skin, an absorbent () disposed thereon, the absorbent () comprising a material capable of absorbing a liquid, and a dissolving solution reservoir () disposed on the absorbent (), the dissolving solution reservoir () containing a dissolving solution () for dissolving a drug and being capable of disrupting a diaphragm () provided the dissolving solution reservoir () and the absorbent () by pressing. A coating containing a dry drug is disposed on the microneedles () and/or the microneedle substrate ().

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Tsukuba, Japan

Toshiyuki Matsudo