Mitsui Chemicals, Inc.

Mitsui Chemicals Agro, Inc.

Toshiyuki Kouno

Hironori Komatsu

Katsutoshi Tsuchiya

Toshiaki Ohara

Hideki Umetani

Hideaki Ikishima

Ryohei Naito

Takeshi Fukumoto

Akihiro Nishida

Satoshi Yutani

Hiroharu Tanikawa

Nobuyuki Fukazawa

Hiroki Ishibashi

Kazuki Kitajima

Tomomi Shirakawa

Masanori Yanagi

Kunihiko Morizane

An object of the invention is to provide compounds of formula (1) or salts thereof which are effective as agricultural and horticultural fungicides. In the formula, R1 represents, for example, a hydroxy group or a cyano group, R2, R3 and R4 are independent of one another and each represent, for example, a hydrogen atom or a halogen atom, R5 represents, for example, a hydrogen atom or a halogen atom, X represents an oxygen atom or a sulfur atom, Y represents, for example, a phenyl group or a pyridyl group, and the bond including the broken line represents a double bond or a single bond.

Pyridone compounds and agricultural and horticultural fungicides containing the same as active ingredients

A compound represented by Formula (1) or a salt thereof is provided. R1 represents a C1-C6 alkyl group optionally substituted, a C1-C6 haloalkyl group or the like, R2 represents a halogen atom, a C1-C6 alkyl group optionally substituted, a C1-C6 alkyloxy group optionally substituted or the like, R3 represents a hydrogen atom, a halgenatom, C1-C6 alkyl group optionally substituted or the like, n represents an integer of 0 to 5, X represents an oxygen atom or a sulfur atom, Y represents a phenyl group or a pyridyl group that is substituted with substituent at an ortho position, and the bond with a broken line indicates a double bond or a single bond. 

Pyridone compounds and agricultural and horticultural fungicides containing said compounds as active ingredient

A method for efficiently purifying 5' protected 2&#x2032;-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5&#x2032; protected 2&#x2032;-deoxypurine nucleoside as an inclusion crystal including a solvent such as that having a nitrile structure in order to purify the 5&#x2032; protected 2&#x2032;-deoxypurine nucleoside at a high purity. This invention enables synthesis of highly purified, protected deoxypurine nucleosides easily on a large scale, which has previously been performed by column chromatography method.

Method for purifying 5' -protected 2&#x2032;  -deoxypurine nucleosides

A method for efficiently purifying 5' protected 2&#x2032;-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5&#x2032; protected 2&#x2032;-deoxypurine nucleoside as an inclusion crystal including a solvent such as that having a nitrile structure in order to purify the 5&#x2032; protected 2&#x2032;-deoxypurine nucleoside at a high purity. This invention enables synthesis of highly purified protected deoxypurine nucleosides easily on a large scale, which has previously been performed by column chromatography method.

Method for purifying 5'-protected 2&#x2032;-deoxypurine nucleosides

This invention provides a method for efficiently purifying 5'-protected thymidines which cannot be efficiently purified by the prior art. Impurities can be separated by obtaining crystals including a carbonyl-containing solvent to provide a highly pure 5&#x2032;-protected thymidine. Thus, this invention allows 5&#x2032;-protected thymidines, which cannot be purified in an industrial scale by the prior art, to be easily provided with a high purity in a large scale.

Method for purifying 5' -protected thymidines and novel derivatives thereof

An efficient method for producing cytidine derivatives that took away the previous drawbacks by efficiently synthesizing cytidine derivatives by utilizing a tertiary amine can be provided.

Process for the preparation of cytidine derivatives

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Chiba, Japan

Toshiyuki Kouno