Shionogi Company Limited

Shionogi Seiyaku Kabushiki Kaisha

Toshiyuki Kato

Mitsuaki Ohtani

Tadashi Yoshida

Yoshimi Kawamura

Koichi Matsumoto

Hiroshi Itazaki

Fumihiko Watanabe

Kaoru Seno

Yozo Hori

Pyrrolidine derivatives having phospholipase A.sub.2 inhibitory activity

The present invention relates to a compound represented by the formula: ##STR1## wherein a and b are each a carbon atom; a bond:

Oxazolinone derivatives having cytosolic phospholipase A.sub.2

Novel carboxylate derivatives exhibiting phospholipase A.sub.2 inhibitory activity are disclosed, Specifically, the following compounds of the formula and pharmaceutically acceptable salts thereof are disclosed: ##STR1## wherein A is hydroxy, amino, or lower alkylamino; R.sup.1 to R.sup.12 are independently hydrogen, methyl, methoxy, or hydroxy, provided that all of R.sup.1 to R.sup.12 are not hydrogen; G.sup.1 is a single bond, or a group of --(CH.sub.2).sub.x O(CH.sub.2).sub.y -- wherein x and y are independently 0-5; G.sup.2 is a single bond, oxygen, sulfur, carbonyl, etc.; G.sup.3 is alkyl, aryl, or a group of the formula: ##STR2## wherein R.sup.13 and R.sup.14 are independently hydrogen, alkyl, aryl, etc.; or R.sup.13 and R.sup.14 may be taken together with the adjacent nitrogen atom to form a heterocyclic group or a group of the formula: ##STR3## wherein Z is a carbon atom or a nitrogen atom, J, K, and L are independently hydrogen or aryl, etc.; p and q are independently 0, 1, or 2; and n is an integer of 1 to 8.

Carboxylate derivatives exhibiting phospholipase A2 inhibitory activity

The present invention relates to a novel aldose reductase inhibitor of the formula: ##STR1## wherein X is methylene or carbonyl;

Aldose reductase inhibitor obtained from Crucibulum sp. RF-3817

The present invention relates to an aldose reductase inhibitor represented by the formula: ##STR1## wherein R.sub.1 is (CH.sub.2).sub.2 COOH and R.sub.2 is phenyl or p-hydroxyphenyl, or R.sub.1 and R.sub.2 are combined together to form a group of the formula: ##STR2## which was isolated from the fermentation products of Chaetomella circinoseta RF-3192.

Aldose reductase inhibitor

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Suita, Japan

Toshiyuki Kato