Sankyo Company, Limited

Toshiyasu Takemoto

Takahide Nishi

Futoshi Nara

Takaichi Shimozato

Takeshi Yamaguchi

Katsuyoshi Nakajima

Takuya Ikeda

Shojiro Miyazaki

Takashi Izumi

Yukiko Iio

A method for suppressing the number of peripheral blood lymphocytes involving administering to a human in need thereof a pharmaceutically effective amount of a compound which is (2R) -2-amino-2-methyl-4-{1-methyl-5-[4-(4-methylphenyl)butanoyl]pyrrol-2-yl}butan-1-ol or a pharmacologically acceptable salt thereof, such as the hydrochloride salt.

Method for suppressing the number of peripheral blood lymphocytes using an amino alcohol compound

The present invention provides a compound having the following general formula (I) which is useful as a neurokinin receptor antagonist: (wherein,

Indanol derivative

Compounds of formula (I) which exhibit excellent immune suppression activity, pharmacologically acceptable salts thereof, esters thereof or other derivatives:wherein Rand Rare a hydrogen atom, an amino protecting group; Ris a hydrogen atom, a hydroxy protecting group; Ris a lower alkyl group; n is an integer from 1 to 6; X is an ethylene group; Y is a C-Calkylene group, a C-Calkylene group substituted with 1 to 3 substituents selected from substituent group a and b; Ris an aryl group; Rand Rare a hydrogen atom, a group selected from substituent group a; with the proviso when Ris a hydrogen atom, Y is not a single bond or a straight chain C-Calkylene group.

Amino alcohol derivatives

Spiropiperidine derivatives

Growing community of inventors

Tokyo, Japan

Toshiyasu Takemoto