Taisho Pharmaceutical Co., Ltd.

Toyama Chemical Co., Ltd.

Toshiya Noguchi

Hiroki Urabe

Taro Kiyoto

Fumihito Ushiyama

Tadashi Tanaka

Yasuhiro Tsutsui

Junichi Ando

Hiromasa Horikiri

Yasunobu Ushiki

Yasuko Kawaguchi

Mai Motono

Mai Yokotani

Yasutaka Baba

Masahiro Takebayashi

Muneo Syoji

A nitrogen-containing heterocyclic compound or pharmaceutically acceptable salt thereof represented by the general formula: which have a potent antibacterial activity and a high safety. Thus, the compounds are useful as antibacterial agents against gram-positive bacteria, gram-negative bacteria and drug resistant bacteria.

Quinolinones and quinoxalinones as antibacterial composition

Disclosed is a compound represented by the general formula: wherein Rrepresents an aryl or heterocyclic group which may be substituted or the like; Xrepresents a C-Calkylene group or the like; X, Xand Xindependently represent NH, a bond or the like; Xrepresents a lower alkylene group, a bond or the like; Yrepresents a bivalent alicyclic hydrocarbon residue which may be substituted or a bivalent alicyclic amine residue which may be substituted; and Z, Z, Z, Z, Zand Zindependently represent a nitrogen atom, a group represented by the formula: CH, or the like, provided that at least one of Z, Z, Zand Zrepresents a nitrogen atom, or a salt thereof, which is useful as an antibacterial agent.

Heterocyclic compound or salt thereof and intermediate thereof

Disclosed is 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)piperidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one monohydrate, which has strong antibacterial activity. The compound is highly safe and useful as an original drug for pharmaceutical preparations. Also disclosed is a method which is useful for producing 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)piperidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one monohydrate.

Naphthyridine derivative monohydrate and method for producing the same

Quinoxalinones as antibacterial composition

Disclosed is a compound represented by the general formula: [wherein Rrepresents an aryl or heterocyclic group which may be substituted or the like; Xrepresents a C-Calkylene group or the like; X, Xand Xindependently represent NH, a bond or the like; Xrepresents a lower alkylene group, a bond or the like; Yrepresents a bivalent alicyclic hydrocarbon residue which may be substituted or a bivalent alicyclic amine residue which may be substituted; and Z, Z, Z, Z, Zand Zindependently represent a nitrogen atom, a group represented by the formula: CH, or the like, provided that at least one of Z, Z, Zand Zrepresents a nitrogen atom] or a salt thereof, which is useful as an antibacterial agent.

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Tokyo, Japan

Toshiya Noguchi