Dai Nippon Printing Co., Ltd.

Takeda Pharmaceutical Company Limited

Scohia Pharma, Inc.

Toshitake Kobayashi

Nobuyuki Negoro

Morihisa Saitoh

Yasufumi Wada

Tsuyoshi Maekawa

Hiroshi Nara

Naoyoshi Noguchi

Koji Watanabe

Satoshi Sasaki

Nobuyuki Takakura

Shigemitsu Matsumoto

Takashi Matano

Hideki Furukawa

Shizuo Kasai

Yasufumi Miyamoto

Jumpei Aida

Yasuhiro Hirata

Seiji Miwatashi

Eiichiro Yokochi

Kazuhiro Takahashi

Haruo Ono

Masashi Yamasaki

Yayoi Nakayama

Yuko Hitomi

Kenichi Tachihara

Masataka Takemoto

Naomi Kitamoto

Takahiro Tanaka

Takashi Iizuka

Norihito Tokunaga

Kazuaki Takami

Kazuhiro Abe

Tomohiro Okawa

Nobuo Saitou

Akito Shibuya

Ayumu Niida

Yoshiaki Netsu

Minoru Ikoma

Taisuke Katoh

Ryoma Hara

Hideto Fukushi

Hideaki Koike

Hiroyuki Motono

A compound represented by the following formula (I): wherein each symbol in the formula is as described herein or a salt thereof has an NRF2 activating activity, and is expected to be useful as a preventive or therapeutic agent for diseases associated with oxidative stress, in particular, hepatic disease (for example, non-alcoholic steatohepatitis (NASH)), cardiovascular disease (for example, heart failure or pulmonary arterial hypertension), lung disease (for example, chronic obstructive pulmonary disease (COPD)), kidney disease (for example, chronic kidney disease (CKD) or acute kidney injury (AKI)), central nervous system disease (for example, Parkinson's disease), mitochondrial disease (for example, Friedreich motor ataxia, mitochondrial myopathy), inflammatory disease (for example, multiple sclerosis (MS), inflammatory bowel disease (IBD)), sickle cell disease, cancer, or the like.

Macrocyclic compound and use thereof

Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.

Aromatic compound

Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy. 

Substituted cyclyl-acetic acid derivatives for the treatment of metabolic disorders

Provided is a compound, such as ethyl 6-((2-chloro-4-fluorobenzyl)sulfonyl) -3-hydroxycyclohex-1-ene-1-carboxylate or an optical isomer thereof, having a superior Toll-like receptor 4 (TLR4) signaling inhibitory action, which may be useful as a prophylactic or therapeutic drug for diseases such as autoimmune diseases and/or inflammatory diseases, or chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver failure, and ischemia reperfusion injury (IRI).

Cyclic compound

The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like. The present invention relates to a compound represented by formula (I) and a salt thereof: wherein, each symbol is explained in greater detail in the specification.

Cyclic compounds

The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like. The present invention relates to a compound represented by formula (I) and a salt thereof: (wherein, each symbol is explained in greater detail in the specification).

There are provided a shaping sheet provided on a surface thereof with a fine irregular shape which is capable of forming a fine pattern with a high-grade feel on a material to be shaped, and is excellent in releasability from the material, as well as a decorative plate shaped by the shaping sheet. The shaping sheet of the present invention includes a substrate, at least an ink layer partially formed on the substrate and a surface shaped layer which is present on and contacted with the ink layer so as to cover a whole surface including both a region where the ink layer is formed and a region where no ink layer is formed, wherein the surface shaped layer is formed by crosslinking and curing an ionizing radiation-curable resin composition, and has a convex shape on a surface thereof which is located in a portion just above the ink layer and in the vicinity of the portion. The shaping sheet is provided on a surface thereof with a fine irregular shape, which is capable of forming a fine pattern with a high-grade feel on a material to be shaped, and excellent in releasability from the material.

Shaped sheet

A decorative material having a pattern on a surface thereof and exhibiting a difference in gloss according to the pattern which is visually recognized as a concave portion, the decorative material further exhibiting not only a good surface strength such as abrasion resistance but also good marring resistance and oil resistance. The decorative material includes at least a substrate, a low-gloss pattern ink layer formed on part of the substrate, and a surface protective layer which is present on and contacted with the low-gloss pattern ink layer so as to cover a whole surface including both a region where the low-gloss pattern ink layer is formed and a region where no low-gloss pattern ink layer is formed.

Decorative material having low-gloss pattern ink layer formed on part of a substrate and a surface protective layer on the pattern in K layer, and decorative plate including such material

There is provided a decorative material comprising at least a substrate, a low-luster pattern ink layer partially formed on the substrate, and a surface protective layer which is present on and contacted with the low-luster pattern ink layer so as to cover a whole surface including both a region where the low-luster pattern ink layer is formed and a region where no low-luster pattern ink layer is formed, wherein the surface protective layer is formed by crosslinking and curing an ionizing radiation-curable resin composition, and provided therein with a low-gloss region which is located in a portion just above the low-luster pattern ink layer and in the vicinity of the portion and visually recognized as a concave portion. The decorative material is provided on a surface thereof with a pattern, and exhibits a difference in gloss according to the pattern which is visually recognized as a concave portion, thereby imparting a good convexo-concave feeling to a surface thereof.

Decorating material

A decorative material including a substrate and an abrasion-resistant coating layer formed thereon. The abrasion-resistant coating layer includes spherical particles (A) having an average particle diameter of 3 to 50 micrometers, and a binder (B) including crosslinkable resins. The amount of the spherical particles (A) is from 5% to 50% by weight of the total amount of the components (A) and (B). The hardness of the spherical particles (A) is higher than of the binder (B), and The average particle diameter d (micrometers) of the spherical particles (A) fulfills the following inequality (1):

Decorative material having abrasion resistance

A printed woodgrain pattern and a lustrous solid printed layer are formed by printing on the back surface of a transparent thermoplastic resin film to obtain a printed film. The printed film and a colored thermoplastic resin film are superposed, the printed film and the colored thermoplastic resin film are laminated to obtain a laminated structure and, at the same time, the laminated structure is embossed from the side of the colored thermoplastic resin film by a doubling embossing method with an embossing die provided with an embossing pattern of ridges and furrows to obtain a decorative sheet. In the decorative sheet, a second and a third embossed pattern each having a cross section having a smooth outline expressed by a periodic function or a pseudoperiodic function are formed in the interfaces between the colored thermoplastic resin film and the lustrous printed layer and between the lustrous printed layer and the transparent thermoplastic resin film, respectively.

Decorative sheet and method for producing the same

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Kanagawa, Japan

Toshitake Kobayashi