Fujisawa Pharmaceutical Company, Ltd.

Toshitaka Manda

Hiroyuki Kikuchi

Kyoichi Shimomura

Masanori Fukushima

Fusako Nishigaki

Yasuji Yamada

Osamu Hirai

Yasumasa Tsukitani

Iwao Shimizu

A vascular permeability suppressant includes an oxaspirooctane derivative of the general formula (I):

Vascular-permeability suppressants

Novel clavulone derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 combine together to form a keto group or either one of R.sup.1 and R.sup.2 is hydrogen atom and another one of them is hydroxy or acetoxy group, R.sup.3 and R.sup.4 are the same or different and are each hydrogen atom or acetoxy group, n is 0 or 1, provided that when the C--C bond between 8 and 12 positions is double bond, n is 0, a, b, c, d and e are each an integer of 1 or 2, and the dotted line means that the C--C bond is a single bond or double bond, or a salt thereof, which have excellent anti-inflammatory activity and anti-tumor activity and hence are useful as an anti-inflammatory agent or anti-tumor agent.

Clavulone derivatives, process for preparing the same, and use of said

Growing community of inventors

Osaka, Japan

Toshitaka Manda