Shionogi Company Limited

Kikusui Seisakusho Ltd.

Toshitada Toyoda

Hidekazu Shodai

Noboru Nagafuji

Yoshitaka Tomoda

Yuka Okada

Chieko Imamoto

Yoshitsugu Oneda

Makoto Kubota

Kentaro Hayashi

Yoshitsugu Muguruma

Mitsutoshi Matsuno

Yoichi Taniguchi

Kazuaki Yoshioka

An oral disintegrating tablet which contains rosuvastatin or a salt thereof and is stable to light is provided. An oral disintegrating tablet stable to light, temperature and humidity can be provided by preparing a multi-layered tablet containing rosuvastatin or a pharmaceutically acceptable salt thereof as an active ingredient, a light stabilizer, and an inorganic salt or a basic oxide.

Multi-layered tablet containing drug unstable to light

A soft capsule in which a shell is filled with fill material, and the fill material is in a solid or semi-solid form at room temperature. The soft capsule may be a chewable capsule, and the fill material may comprise a low melting point additive. The content of the low melting point additive may be 10% or more with respect to the total weight of the fill material, and may have a melting point of about 20 to 50&#xb0; C. The low melting point additive may be selected from the group consisting of chocolate base, lard, coconut oil and macrogol (polyethylene glycol) as well as a combination thereof.

Chewable soft capsule having improved ingestion property and method for producing same

A nozzle structure is mounted in a compression molding machine that compresses using a punch a powder material filled in a die to manufacture a compressively molded product, and sprays a lubricant at least toward a tip of the punch prior to filling the powder material and includes a guide path that guides the lubricant, and a spraying portion that is provided at an end of the guide path so as to communicate therewith and that sprays the lubricant guided along the guide path so as to be substantially aligned with a predetermined straight line intersecting at least in a direction of relative displacement of the punch.

Nozzle structure

Chewable soft capsules having improved administration properties and process for producing the same

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Hyogo, Japan

Toshitada Toyoda