Ajinomoto Co., Ltd.

Other

Kazuo Sugamura

Toshiro Shimamura

Junji Hamuro

Toshikazu Takeshita

Manabu Suzuki

Harumi Nakazawa

Masataka Nakamura

Hironobu Asao

Yuka Kanayama

Shinsuke Taki

The present invention relates to an IL-2 receptor .gamma. chain molecule, a DNA-sequence encoding the IL-2 receptor .gamma. chain molecule, a vector possessing said DNA-sequence, a cell transformed with said vector, a method for the production of an IL-2 receptor .gamma. chain molecule by culturing of said cell, an immune response regulatory agent comprising an IL-2 receptor .gamma. chain molecule and an antibody to an IL-2 receptor .gamma. chain molecule.

Human IL-2 receptor .gamma.-chain molecule antibody

The present invention relates to (1) polypeptide capable of binding to .beta. chain of IL-2 receptor and having the inhibitory activity of the binding between IL-2 and .beta. chain of IL-2 receptor, and (2) the process of producing the polypeptide, especially in E. coli as a host. THe polypeptide according to the present invention and the pharmaceutical composition containing the polypeptide are useful to prevent rejection of organ transplantation and also to cure autoimmune diseases.

Polypeptides capable of binding to heavy chains of IL-2 receptors

A polypeptide which specifically binds to the .gamma.-chain of the human interleukin-2 receptor and selectively inhibits the binding of the .gamma.-chain of human interleukin-2 receptor to the .beta.-chain of the same is provided. The polypeptide has an activity of blocking the human interleukin-2 response. Also provided are an immunosuppressant containing the polypeptide, a DNA gene coding for the polypeptide, a recombinant DNA having the gene, a transformant having the recombinant DNA, and a method for producing the intended polypeptide by incubating the transformant. The novel polypeptide can be used independently, or with substances capable of inhibiting the binding of interleukin-2 to the interleukin-2 receptor, as a medicine for preventing the rejection of grafts after transplantation and also for curing inflammatory diseases such as allergic diseases and autoimmune diseases.

.gamma.-chain humaninterleukin-2 receptor polypeptide and method of

The invention provides a method for detecting (1) leukemia, (2) cancer, (3) autoimmune disorder, (4) inflammatory disorder, (5) allergic disorder or (6) viral infection, characterized by measuring soluble, human interleukin-2 receptor .gamma.-chain molecules existing in a human body fluid by an immunochemical method using an antibody/antibodies specifically reacting with human interleukin-2 receptor .gamma.-chain molecule, and a reagent for the detection.

Method and reagent detecting human disorders

The present invention relates to an IL-2 receptor .gamma. chain molecule, a DNA-sequence encoding the IL-2 receptor .gamma. chain molecule, a vector possessing said DNA-sequence, a cell transformed with said vector, a method for the production of an IL-2 receptor .gamma. chain molecule by culturing of said cell, an immune response regulatory agent comprising an Il-2 receptor .gamma. chain molecule and an antibody to an IL-2 receptor .gamma. chain molecule. Both the Il-2 receptor .gamma. chain molecule and the antibody to the IL-2 receptor .gamma. chain molecule are very useful immune response regulatory agents.

Human IL-2 receptor .gamma. chain molecule

Peptides which inhibit the binding of human IL-6 to human IL-6 receptor are useful as a treatment for diseases induced or aggravated by IL-6. DNA fragments, vectors, transformants, and methods useful for preparing such peptides are described.

Growing community of inventors

Kawasaki, Japan

Toshiro Shimamura