Pola Chemical Industries, Inc.

Toshiro Majima

Toshimitsu Suzuki

Takuji Nakashima

Masayuki Yuasa

Yukio Kawazu

Akira Nozawa

Takao Itoh

Hiroyuki Takimoto

Kouji Yokoyama

Takao Ito

Ryoichi Nagatomi

Tasuke Konno

Toshikazu Awataguchi

Yoshimi Yano

Yuichi Yokomizo

Amine derivatives

Disclosed is a method for differentiating human peripheral blood granulocytes which comprises cultivating the granulocytes in the presence of an interferon and acting an immune complex on said granulocytes in the presence of a chemiluminescent substance, and measuring the chemiluminescent amounts induced. It contributes to the screening of patients suffering from serious infectious diseases or a range of inflammations, and is advantageous for monitoring the curative effects for those patients.

Method for differentiating human peripheral blood granulocytes

Novel amine derivatives having an excellent antimycotic effect represented by general formula (1) below and salts thereof are provided.

Antifungal amine derivatives and processing for producing the same

This invention relates to compounds represented by the following formula (1): ##STR1## wherein R.sup.1 represents a substituted or unsubstituted phenyl group, R.sup.2 represents a substituted or unsubstituted phenylene group, R.sup.3 represents a substituted or unsubstituted phenyl group or an aliphatic hydrocarbon group containing at least four .pi. electrons, R.sup.4 represents an alkyl group having 1 to 4 carbon atoms, and m and n individually represent integers of from 1 to 4, or salts thereof, and also to compositions containing the same. These compounds have antifungal activities and are useful as drugs.

Antifungal agents

This invention relates to compounds represented by the following formula (1): ##STR1## wherein R.sup.1 represents a substituted or unsubstituted aromatic hydrocarbon group having 6 to 18 carbon atoms, R.sup.2 represents a hydrogen atom or a substituted or unsubstituted aromatic hydrocarbon group having 6 to 18 carbon atoms, R.sup.3 represents an alkyl group having 1 to 4 carbon atoms, R.sup.4 represents a substituted or unsubstituted phenyl group or an aliphatic hydrocarbon group containing at least four .pi. electrons, and m and n individually represent integers of from 1 to 4, or salts thereof, and also to compositions containing the same. These compounds have antifungal activities and are useful as drugs and the like.

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Yokohama, Japan

Toshiro Majima