Chugai Seiyaku Kabushiki Kaisha

Toshiro Kozono

Tsutomu Sato

Shojiro Kadono

Haruhiko Sato

Takuya Shiraishi

Toru Esaki

Kunihiro Hattori

Hisanori Takanashi

Masayuki Haramura

Tomokazu Ozaki

Takaki Koga

Akihisa Sakamoto

Shinya Fujiwara

Ken-ichiro Kotake

A compound of Formula (1):&#x2003;wherein A crystal of a complex between factor VIIa/human soluble tissue factor and a low-molecular weight reversible factor VIIa inhibitor. A medium carrying a part or all of structure coordinate data of a complex between human factor VIIa/human soluble tissue factor and a low-molecular weight reversible factor VIIa inhibitor, obtainable by X-ray crystal structure analysis of the crystal. A method for computationally designing a low-molecular weight reversible factor VIIa inhibitor using the coordinate data.

Peptide derivatives

The compounds of the invention are compounds represented by the following general formula (1):wherein E represents one selected from the group consisting of a methylidyne group and a nitrilo group, Rrepresents one selected from the group consisting of optionally substituted aryl groups and optionally substituted heteroaryl groups, Rrepresents one selected from the group consisting of a hydrogen atom and alkyl groups, Wrepresents an amino acid residue, A represents one selected from the group consisting of a carbonyl group and a sulfonyl group, Xrepresents one selected from the group consisting of optionally substituted alkylene groups and optionally substituted alkenylene groups, and p represents 0 or 1;and their pharmacologically acceptable salts, which exhibit thrombopoietin-like activity.

Compounds exhibiting thrombopoietin-like activities

The present invention has as its object providing phenethylamine derivatives that typically function as a motilin receptor antagonist and which are useful as medicines. The invention provides compounds represented by the general formula (1):

Phenethylamine derivatives

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Shizuoka, Japan

Toshiro Kozono