Toray Industries, Inc.

Toshio Yoshioka

Masaharu Shimamura

Kazuo Teramoto

Takashi Kawai

Tomoko Katsu

Seiichi Yoshikawa

Koji Watanabe

Yuji Ueda

Masahiro Henmi

Masaaki Shimagaki

Kouichi Saito

Takeo Matsunase

Syunroku Tohyama

Nami Kubo

Ken Noyorio

Yoshiki Yamamoto

An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. The excessive immunosuppressive substance may be involved in growth of cancer cells. The adsorbent for immunosuppressive substance includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column contains the adsorbent of the invention. A method for treating cancer carries out extracorporeal perfusion using the extracorporeal perfusion column. A method of adsorbing the transforming growth factor &#x3b2; which is combined with another protein, includes adsorbing the transforming growth factor &#x3b2; and protein on an adsorbent containing a water-insoluble carrier to which quaternary ammonium groups each having 3 to 18 carbon atoms per one nitrogen atom are attached, and having a specific surface area of 0.1 mor more per gram.

Method of adsorbing transforming growth factor &#x3b2;

Disclosed are a porous membrane which is made from a material containing, as its main component, a polytetrafluoroethylene resin, and a method of producing a porous membrane comprising forming a hollow or sheet-like film from a mixture of a polytetrafluoroethylene resin dispersion and a fiber-forming polymer, heat-treating the film at a temperature not lower than the melting temperature of the resin, and removing the fiber-forming polymer. Production of polytetrafluoroethylene porous membranes of a variety of pore sizes and porosities is possible by suitably varying the type and amount of additives added to an original liquid. The membrane finds spreading use in the field of separation in high-temperature and strong decomposing or strong dissolving mediums.

Polytetrafluoroethylene resin porous membrane, separator making use of

The present invention relates to a new anion exchanger with excellent heat resistance and its use for treating a fluid to remove unwanted or unnecessary substances from it. The anion exchanger has functional groups of the formula: ##STR1##

Anion Exchanger and a method for treating a fluid

The present invention relates to a method for purification of liquids. Fur particulars, the present invention relates to a method for purifying more precisely liquids in atomic power related fields, using a mixture of a polymer in which carboxyl groups are grafted onto a polyamide or a polyester as a cation exchanger and an anion exchanger.

Method for purifying liquids

A filter for tobacco smoke containing a fibrous ion exchange resin and a fibrous ion exchange resin wherein at least a part of the fiber is fibrillated or split for use in making the filter is disclosed. The filter efficiently removes substances harmful to the human body, e.g., ionic, polar, carcinogenic, and mutagenic substances, and nicotine and tar from tobacco smoke.

Tobacco filter and fibrous ion exchange resin

Method of ion-exchanging and/or adsorption

A metal ion that inhibits enzyme deactivation is bonded to a carrier and inhibits enzyme deactivation when contacted with a substrate for the enzyme. A carrier-bound metal ion such as ions of iron is particularly suitable for inhibiting deactivation of glucose isomerase when isomerizing glucose to fructose. Glucose isomerase life is remarkably prolonged by contacting carrier-bound iron ions with a glucose substrate solution prior to isomerizing with glucose isomerase.

Enzyme reaction method for isomerization of glucose to fructose

An enzymatically active product for use in isomerization of glucose into fructose is provided. The active product comprises an organic polymeric material predominantly comprised of a monovinyl aromatic compound polymer having .beta.-aminopropionamidomethyl group as side chains represented by the formula I: ##STR1## wherein R.sub.1 is selected from H, C(1-6) alkyl and C(2-6) hydroxyalkyl, R.sub.2 is selected from C(1-6) alkyl, C(2-6) hydroxyalkyl, ##STR2## (where X, Z.sub.1 and Z.sub.2 are selected from H and C(1-6) alkyl, and n is from 2 to 6), or R.sub.1 and R.sub.2 form together with the N atom, to which R.sub.1 and R.sub.2 are bonded, heterocyclic structure of the formula: ##STR3## where A is --CH.sub.2 --, --O-- or --NR.sub.6 -- (wherein R.sub.6 is H or C(1-6) alkyl), and R.sub.3, R.sub.4 and R.sub.5 are selected from H and methyl. The organic polymeric material has glucose isomerase immobilized with the .beta.-aminopropionamidomethyl group side chain of the organic polymeric material.

Process for isomerizing glucose to fructose

An enzymatically active product for use in isomerization of glucose into fructose is provided. The active product comprises an organic polymeric material predominantly comprised of a monovinyl aromatic compound polymer having .beta.-aminopropionamidomethyl group as side chains represented by the formula I: ##STR1## wherein R.sub.1 is selected from H, C(1-6) alkyl and C(2-6) hydroxyalkyl, R.sub.2 is selected from C(1-6) alkyl, C(2-6)hydroxyalkyl, ##STR2## (where X, Z.sub.1 and Z.sub.2 are selected from H and C(1-6) alkyl, and n is from 2 to 6), or R.sub.1 and R.sub.2 form together with the N atom, to which R.sub.1 and R.sub.2 are bonded, a heterocylic structure of the formula: ##STR3## where A is --CH.sub.2 --, --O-- or --NR.sub.6 -- (wherein R.sub.6 is H or C(1-6) alkyl), and R.sub.3, R.sub.4 and R.sub.5 are selected from H and methyl. The organic polymeric material has glucose isomerase immobilized with the .beta.-aminopropionamidomethyl group side chain of the organic polymeric material.

Growing community of inventors

Otsu, Japan

Toshio Yoshioka