Teikoku Seiyaku Co., Ltd.

Nagase Co., Ltd.

Toshio Yokoi

Kunio Kosaka

Yoshio Okada

Lawrence H Lazarus

Toshitsugu Miyazaki

Yuko Tsuda

Sharon D Bryant

1. A peptide derivative represented by the following formula (1) or a salt thereof;wherein Ris hydrogen atom or methyl group, Ris hydrogen atom or hydroxy group and n is an integer of 1-8, provided that Ris hydrogen atom when Ris hydrogen atom, which has specific and high binding affinity with the &#x3bc;-opioid receptor.

Opioid derivative

A novel carnosic acid derivative for promoting the synthesis of nerve growth factor (NGF), a composition comprising the carnosic acid derivative as an effective ingredient, as well as, a method of promoting the synthesis of NGF comprising administering an effective amount of the carnosic acid derivative as an effective ingredient to a subject requiring such promotion. The carnosic acid derivative, composition and method according to the present invention can safely and efficiently promote the production of NGF in the living body, without being accompanied by a side effect such as a loss of a quantitative balance of hormones in the living body.

Carnosic acid derivatives for promoting synthesis of nerve growth factor

Growing community of inventors

Akashi, Japan

Toshio Yokoi