Astellas Pharma Gmbh

Wakunaga Pharmaceutical Co., Ltd.

Hitachi-johnson Controls Air Conditioning, Inc.

Toshio Yamanaka

Satoshi Inoue

Hidenori Ohki

Kohji Kawabata

Shinya Okuda

Takuya Makino

Kenji Itoh

Ayako Toda

Keiji Misumi

Seiji Yoshimura

Minoru Yasuda

Masahiro Neya

Yukiko Yamagishi

Eisaku Tsujii

Kenji Satoh

Kazunori Kamijyo

Yoshiyuki Yamada

Kenji Murano

Koji Utsumi

Hiroaki Mizuno

Shigeki Kunikawa

Junya Ishida

Hiroaki Ohtake

Yu Harayama

Masaru Oogaki

Kenji Sato

Hitomi Ogino, Legal Representative

Tetsuya Ogino, Legal Representative

Tomomi Takezawa, Legal Representative

Hisashi Akamatsu

Masaru Ohgaki

Hidetaro Kayanuma

A screw rotor lead correction calculation device includes an initial data input section configured to input an error as a distance with respect to a reference lead at each axial position of a rotor groove portion of a screw rotor, and a processing machine input correction amount/position output section configured to compute and output, based on the error as the distance input to the initial data input section, a lead correction amount with respect to the reference lead and a lead correction starting position as an axial position for starting lead correction. With this configuration, correction data for obtaining a screw rotor with a high-accuracy lead can be obtained from a lead error with respect to a reference lead in a screw rotor obtained by ground finish of the material of the screw rotor.

Screw rotor processing method and screw rotor lead correction calculation device

The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, a process for preparation thereof, a pharmaceutical composition comprising the same, and a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.

Cyclic peptide compounds

The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, to a process for preparation thereof comprising a rearrangement reaction under a mild acidic condition and the following amino acid changing reactions etc., to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.

The present invention relates to a compound of the formula [I]:  

Cephem compounds

The present invention relates to a compound of the formula [I]: wherein A is lower alkylene or lower alkenylene; Ris lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl or protected amino(lower)alkyl, and Ris hydrogen or amino protecting group, or Rand Rare bonded together and form lower alkylene; Rand Rare independently amino or protected amino; and Ris carboxy or protected carboxy, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.

The present invention relates to a compound of the formula [I]: wherein 

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Tokyo, Japan

Toshio Yamanaka