Nippon Zoki Pharmaceutical Co., Ltd.

Toshio Yamada

Ken-ichi Kageyama

Koichi Yamanishi

Antiviral Ara-A derivatives having resistance to metabolism by adenosinedeaminase (ADA) are 2-substituted arabinosyladenine derivatives represented by the formula (I) and pharmaceutically acceptable salts and hydrates thereof:

Arabinosyladenine derivatives

The present invention relates to novel adenosine derivatives having the formula (I):

Adenosine derivatives and pharmaceutical composition thereof

The present invention relates to adenosinedeaminase inhibitors containing at least one O-alkylated moiety derivative and the pharmaceutically acceptable salts thereof. The pharmaceutical compositions of the present invention include adenosinedeaminase inhibitors containing at least one of the compounds represented by Formula (I): ##STR1## wherein each of R.sub.1, R.sub.2, and R.sub.3 are the same or different and is hydrogen or alkyl;

Method for treating allergic diseases with adenosine derivatives

The present invention relates to adenosine deaminase inhibitors containing at least one O-alkylated moiety and the pharmaceutically acceptable salts thereof. The pharmaceutical compositions of the present invention include adenosine deaminase inhibitors containing at least one of the compounds represented by Formula (I): ##STR1## wherein each of R.sub.1, R.sub.2, and R.sub.3 are the same or different and is hydrogen or alkyl;

Adenosine deaminase inhibitor

The present invention relates to novel adenosine derivatives having the formula (I): ##STR1## wherein R is a lower alkyl group; R' is hydrogen or a lower alkyl group; X is a cycloalkyl group, an alkyl group having at least one hydroxy group, an alkyl group having at least one phenyl group, a bicycloalkyl group, a naphthylalkyl group, an acenaphthylenylalkyl group or a group of the formula (II) or (III); ##STR2## Z is hydrogen, a hydroxy group or a lower alkoxy group, Q is hydrogen or a hydroxy group, A is --CH.sub.2 --, --O--, --S-- or shows a direct connection; Y is --(CH.sub.2).sub.n -- or shows a direct connection; n is an integer of 1 to 3; and the broken line is a double bond or a single bond. and pharmaceutically acceptable salt thereof, which are useful as antihypertensive agents.

Novel adenosine compounds of the formula (I): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or a lower alkyl group; X is hydrogen, a lower alkyl group, an amino group or halogen; and Y is hydrogen or a lower alkyl group, exhibit utility as antihypertensive agents.

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Hyogo, Japan

Toshio Yamada