Taisho Pharmaceutical Co., Ltd.

Lion Akzo Co., Ltd.

Toshio Yajima

Kuniaki Ishii

Shigeru Itai

Akiko Kawashima

Ikuo Koyama

Kimihide Shimano

Masami Nemoto

Hidefumi Hayashi

Hiroshi Ikuta

Nobuo Umeki

Nobuyoshi Tsukui

Kouji Suetake

Disclosed herein are oral preparations and their production process. The oral preparations are each composed of a complex and a coating composition applied on the complex. The complex has been obtained by dispersing or dissolving a drug having an unpleasant taste and a gastric high-molecular compound in a low melting-point substance heated to and molten at its melting point or higher and granulating the resulting mixture. The coating composition is composed of an insoluble high-molecular compound and a disintegrator at a weight ratio of from 80:20 to 99:1. In the form of microparticles or the like that contain the drug having the unpleasant taste, each oral preparation according to the present invention can maintain the masking of the unpleasant taste of the drug and the release profile of the drug even under acidic conditions.

Oral preparations and process for production thereof

To provide: a carboxamide derivative having reduced content of amide ester; a method for producing thereof; and a detergent composition containing the carboxamide derivative and having excellent low-temperature stability. One method for producing a carboxamide derivative is to react carboxamide, produced with a manufacturing method of carboxamide including 0.02% by weight to 0.18% by weight of amide ester, with hydrogen peroxide, wherein the method includes a carboxamide synthesis process to synthesize carboxamide by reacting diamine with fatty acid ester at a molar rate of 1.20 to 1.60. Another method for producing a carboxamide derivative is to react the carboxamide with monohaloalkylcarboxylic acid or a salt thereof. A carboxamide derivative is produced by the method for producing a carboxamide derivative. A detergent composition includes the carboxamide derivative. The carboxamide derivative is preferably amidoamine oxide or amide betaine.

Carboxamide derivative, processes for producing the same, and detergent composition

A production process for a carboxylic amide compound in which color tone stability after the passage of time is good and in order to provide production processes for betaine, a quaternary ammonium salt and an amine salt using the above carboxylic amide compound, a production process for carboxylic amide and derivatives thereof characterized by reacting higher fatty acid or an ester thereof represented by the following Formula (1) with diamine represented by the following Formula (2) under the presence of an organic phosphonic acid compound represented by the following Formula (3) or adding the organic phosphonic acid compound after the reaction or after removing excess diamine after the reaction:R&#x2014;COOR&#x2003;&#x2003;(1) wherein each of the R and Z groups and n are defined.

Production process for carboxylic amide and derivatives thereof

Taste masking pharmaceutical composition for oral administration

Taste masking pharmaceutical composition

Growing community of inventors

Tokyo, Japan

Toshio Yajima