Suntory Limited

Other

Daiichi Suntory Pharma Co., Ltd.

Suntori Limited

Toshio Tatsuoka

Kunihiro Sumoto

Kenji Suzuki

Seiji Miyano

Fumio Satoh

Takafumi Ishihara

Kayoko Nomura

Akira Mizuno

Hidetsura Cho

Katsuhide Kamei

Makoto Shibata

Norio Inomata

Hirokazu Annoura

Mikiko Hamaguchi

Kayoko Imao

Noriko Maeda

Shigeki Tamura

Atsuko Fukunaga

Mayumi Uesugi

Mikiko Miya

Shinsuke Matsuki

Teruyoshi Inoue

Yuzo Nakagawa

Shizuo Nakamura

Toshihiro Nakanishi

Adrian John Folkes

Masashi Matsui

David James Hardick

Tadashi Honda

Hamish Ryder

Martin A Hayes

Jenny S Tang

Mika Nakajima

Ichiro Hirotsu

Kastuhide Kamei

Masanori Kawai

A method of production of 2,4&prime;-dipyridyl derivatives by a cross coupling reaction of a 2-halopyridine derivative and a 4-halopyridine using a nickel complex catalyst and a method of separation of a 2,4&prime;-dipyridyl derivative from a mixture of dipyridyl isomers containing a 2,2&prime;-dipyridyl derivative, 2,4&prime;-dipyridyl derivative, and 4,4&prime;-dipyridyl by using a dilute aqueous copper sulfate solution to insolubilize and remove the 2,2&prime;-dipyridyl derivative and 4,4&prime;-dipyridyl are disclosed.

Method of production and method of separation of 2,4&prime;-dipyridyl derivatives and methods of production of benzoxazepine derivatives and salts thereof

Medicament for the alleviation or treatment of symptom derived from the ischemic disease and compound useful thereof

Pyrimidine derivatives and their salts, useful for making benzoxazepine derivatives

A compound selected from the group consisting of a 5,6-dihydro-&agr;-pyrone of formula (I):

Cytokine production inhibitors

A benzoxazepine derivative having the general formula (I) and its salts and medicaments containing the same as effective ingredients:

Benzoxazepine derivatives and their salts and medicaments containing the same

Process of production of 4-substituted-3-halogeno-1,4-benzoxazepine

Method of production and method of separation of 2,4'-dipyridyl

Medicament for the alleviation or treatment of symptom derived from

Synthetic method of hymenialdisine and its derivatives and their

Disclosed herein are pyrroloazepine derivatives having anti-.alpha..sub.1 activity and anti-serotonin activity represented by the following formula (I): ##STR1## wherein R means a hydrogen atom, a linear or branched C.sub.1-6 alkyl group or a C.sub.7-10 aralkyl group, A denotes a linear or branched C.sub.2-10 alkylene, alkenylene or alkynylene group, Z stands for O, NOR.sub.1 or NOCOR.sub.5 in which R.sub.1 and R.sub.5 is a hydrogen atom or an alkyl, aryl or aralkyl group, and Y means a particular piperidinyl or pyrrolidinyl group; and salts thereof. Their preparation processes are also disclosed.

Pyrroloazepine derivatives

A cyclopropachromen derivative represented by formula (I): ##STR1## The compounds are capable of promoting the extension of nerve dendrites and are useful as improving and treating agents for cerebral organic disorders and psychic function disorders.

Cyclopropachromen derivatives

Pyrroloazepine compound

Pyrroloazepine derivative

Disclosed herein are pyrroloazepine derivatives, which are useful as therapeutics for circulatory diseases, represented by the following formula (I): ##STR1## wherein R means a hydrogen atom, a linear or branched C.sub.1-6 alkyl group or a C.sub.7-10 aralkyl group, A denotes a linear or branched C.sub.2-10 alkylene, alkenylene or alkynylene group, Z stands for O, NOR.sub.1 or NOCOR.sub.5 in which R.sub.1 and R.sub.5 is a hydrogen atom or an alkyl, aryl or aralkyl group, and Y means a particular piperidinyl or pyrrolidinyl group; and salts thereof. Their preparation processes are also disclosed.

A therapeutically effective antipsychotic preparation comprising a fused cyclic compound for the treatment of diseases involving the serotonergic pathway having the formula (I) or salts thereof: ##STR1## wherein both of A and B are carbonyl groups, or one represents a methylene group and the other a carbonyl group, Z represents a sulfur atom, or a nitrogen atom which may be substituted, or a methylene group, R represents an aromatic or heterocylcic group, which may be substituted, X represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.5 lower alkyl group, a C.sub.1 -C.sub.5 lower alkoxy group, a C.sub.7 -C.sub.9 arylalkoxy group, a C.sub.1 -C.sub.5 lower acyloxy group, a C.sub.7 -C.sub.10 arylcarbonyloxy group, a hydroxy group, a nitro group or an ester group, and n is an integer of 2 to 10.

Fused 7-membered cyclic compound and antipsychotic preparation

Growing community of inventors

Nishinomiya, Japan

Toshio Tatsuoka