Japan Tobacco Inc.

Toshio Taniguchi

Taku Ikenogami

Atsushi Hagiwara

Hiroshi Nakamura

Hisashi Shinkai

Daisuke Takahashi

Mitsuru Takahashi

Hironobu Nagamori

Kimiya Maeda

Akio Iida

Yasunori Suzuki

Yasuhiro Ohe

Kazunori Kurihara

Kenya Madono

Yasuko Mera

Yukako Sumida

Naoya Odani

Shizue Watanabe

Takashi Kawai

The present invention relates to an ester represented by the formula [1]: or its pharmaceutically acceptable salt, or use of the same. The compound represented by the formula [1] or its pharmaceutically acceptable salt is useful as an agent for the treatment or prophylaxis of hyperlipidemia or the like, since it disappears very rapidly in the living body and has an excellent MTP inhibitory activity.

Ester derivatives and medicinal use thereof

A dibenzylamine compound represented by the formula (1) wherein Rand Rare each a Callyl group optionally substituted by halogen atoms and the like; R, Rand Rare each a hydrogen atom, a halogen atom and the like, or Rand Rmay form, together with carbon atoms bonded thereto, a homocyclic or heterocyclic ring optionally having substituent(s); A is &#x2014;N(R)(R) and the like; ring B is an aryl group or a heterocyclic residue; Ris a hydrogen atom, a halogen atom, a nitro group, a Callyl group and the like; n is an integer of 1 to 3, a prodrug thereof and a pharmaceutically acceptable salt thereof show selective and potent CETP inhibitory activity, and therefore, they can be provided as therapeutic or prophylactic agents for hyperlipidemia or arteriosclerosis and the like.

Dibenzylamine compounds and pharmaceutical use thereof

A novel therapeutic agent for hyperlipidemia, which is an ester compound represented by the formula (1&#x2033;) (wherein The therapeutic agent selectively inhibits MTP in the small intestine, thus causes no such side effect as a fatty liver.

Ester compound and medicinal use thereof

A therapeutic agent for hyperlipidemia which has no side effects on the liver unlike conventional MTP inhibitors and has excellent MTP inhibitory activity. Also, provided is an ester compound represented by the general formula (1): or a pharmaceutically acceptable salt thereof.

Ester derivatives and medical use thereof

A dibenzylamine compound represented by the formula (1) wherein Rand Rare each a Calkyl group optionally substituted by halogen atoms and the like; R, Rand Rare each a hydrogen atom, a halogen atom and the like, or Rand Rmay form, together with carbon atoms bonded thereto, a homocyclic or heterocyclic ring optionally having substituent(s); A is&#x2014;N(R) (R) and the like; ring B is an aryl group or a heterocyclic residue; Ris a hydrogen atom, a halogen atom, a nitro group, a Calkyl group and the like; n is an integer of 1 to 3, a prodrug thereof and a pharmaceutically acceptable salt thereof show selective and potent CETP inhibitory activity, and therefore, they can be provided as therapeutic or prophylactic agents for hyperlipidemia or arteriosclerosis and the like.

Dibenzylamine compound and medicinal use thereof

Growing community of inventors

Osaka, Japan

Toshio Taniguchi