Hitachi, Ltd.

Canon Kabushiki Kaisha

Fujitsu Corporation

Takeda Pharmaceutical Company Limited

Renesas Technology Corp.

Sony Corporation

Mie University

Ftex, Incorporated

Sakura Sogyo Co., Ltd.

Toshio Tanaka

Yasuhito Shimada

Takeshi Miyazaki

Kohei Watanabe

Tsuyoshi Nomoto

Shigeyuki Nishitani

Hiroyuki Mano

Taichi Shintou

Masaaki Kitajima

Hidehiko Mayumi

Yuhei Nishimura

Takeaki Kobayashi

Sumio Nakagawa

Naruhiko Kasai

Hiroshi Banno

Takaharu Hirayama

Masahiro Kawasaki

Koichi Kimura

Kunihiro Katayama

Takashi Tsunehiro

Nagamasa Mizushima

Tetsuya Suzuki

Motoyasu Tsunoda

Yasushi Fukunaga

Toshimi Yokota

Hidekazu Tokuhara

Masaki Miura

Yasuyoshi Arikawa

Hiroko Sato

Yasutomo Tsuji

Tatsuzo Hamada

Kenzi Toudo

Shinji Wakisaka

Keiko Gunji

Tomihisa Hatano

Kenji Sakata

Mitsutoshi Uchida

Kazuko Hasegawa

Koji Ono

Tsutomu Furuhashi

Masahiro Ito

Toshio Futami

Yohei Miyauchi

Akihisa Inatani

Toshifumi Arai

Hironobu Maezaki

Kohji Takahashi

Jinichi Yonemori

Shigeo Tsujioka

Yasuhiro Imaeda

Yoshihiro Kajiyama

Yasuhiro Hirata

Nobuki Sakauchi

Motoshi Miyanaka

Nobuo Cho

Ryo Mizojiri

Moriteru Asano

Douglas Robert Cary

Akinori Toita

Nobuo Shibasaki

Hironori Kokubo

Masaki Mega

Jun Fujimoto

Hiroyuki Sakai

Koichi Sano

Satoshi Sasaki

Shiro Baba

Masashi Hirose

Yukio Kobayashi

Soshiro Kuzunuki

Makoto Kamata

Hiroshi Shojima

Keiichi Kurakazu

Takanaga Yamazaki

Ryo Fujii

Norihito Tokunaga

Taketoshi Okubo

Shinichi Imamura

Yoshiteru Ito

Yuya Oguro

Nobuyuki Takakura

Shigemitsu Matsumoto

Mitsuhiro Ito

Makoto Kobayashi

Taku Kamei

Naoko Kasai

Shuhei Ikeda

Jun'ichi Taguchi

Takeshi Wakabayashi

Noriyuki Nii

Kaoru Takahashi

Youichi Kawakita

Shigenori Sasaki

Takashi Fujimaki

Kenjiro Yasunari

Yoshiharu Nagayama

Takuya Fujimoto

Kohji Fukatsu

Mie Okano

Kazuhisa Ishida

Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I):

Nitrogen containing heterocycles as CDK12 inhibitors

Provided is a heterocyclic compound that can have an antagonistic action on an NMD A receptor containing the NR2B subunit and that is expected to be useful as a prophylactic or therapeutic agent for depression, bipolar disorder, migraine, pain, peripheral symptoms of dementia and the like. A compound represented by the formula (I), wherein each symbol is as defined in the DESCRIPTION, or a salt thereof.

Heterocyclic compound and use thereof

Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

Heterocyclic compound

An electrophotographic member comprises a base member and an elastic layer on the base member. The elastic layer contains a silicone rubber, an ionic electroconductive agent, and an inorganic particle, and the inorganic particle contains a hydroxide of at least one of magnesium or aluminum, and has a silicon atom on a surface thereof in an amount of 0.50 to 2.00 atomic %. An aqueous dispersion of which 5 mg of the inorganic particle is dispersed in 10 ml of water has a turbidity of 200 NTU or more and 1,240 NTU or less.

Electrophotographic member and electrophotographic image forming apparatus

An electrophotographic member has a base layer, an elastic layer, and a surface layer on the elastic layer, in this order in a thickness direction, wherein the surface layer includes a urethane resin, a perfluoropolyether compound including a specific repeating structure, and a polyol compound having a specific structure.

Provided is a compound that can have an effect of inhibiting MALT1 and is expected as useful as a prophylactic or therapeutic drug for cancer, etc. A compound represented by formula (I) [wherein each symbol is as defined in the description], a salt thereof, or a cocrystal, a hydrate or a solvate of the same.

To provide an electrophotographic member high in volume resistivity uniformity even in application of a high voltage such as 1,000 V. The electrophotographic member includes a base material and an elastic layer on the base material, the elastic layer containing a silicone rubber and an ionic liquid, and the ionic liquid including a cation modified by a dimethylsiloxane chain, and an anion.

Electrophotographic member, method for producing electrophotographic member, and electrophotographic image forming apparatus

An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. The present invention provides a cancer cell inhibitory drug comprising at least one compound represented by general formula (1) as an active ingredient 

Method of detecting cancer stem cell, method of screening cancer stem cell, and method of inhibiting cancer stem cell

An imaging plate includes a plurality of wells individually accommodating little fishes, and the little fishes inside the wells are imaged from bottom portions of the wells. In order to adjust imaging posture or imaging positions of the little fishes inside the wells, an imaging little fish management device includes a water unit which supplies and discharges water into and from each well of the imaging plate. The water inside each well flows through a discharge hole provided laterally at a lowermost portion of each well. The water unit is also used to breed the little fishes of the wells of the imaging plate.

Imaging little fish management device and little fish imaging plate used in the same

Provided is an evaluation probe capable of optically evaluating permeability of a substance through a central nervous system tissue. Also provided is an evaluation method for permeability of a substance through a central nervous system tissue using an evaluation probe for central nervous system permeability. Also provided is a screening method using an evaluation probe for central nervous system permeability. The evaluation probe for central nervous system permeability includes, as an active ingredient, at least one kind of compound represented by the following general formula (1). 

Evaluation probe for central nervous system permeability, evaluation method for central nervous system permeability, and screening method using an evaluation probe for central nervous system permeability

A group supporting apparatus and related computer readable recording medium to execute a process including: collecting input contents, which are input by participants via terminals, from the terminals; arranging the collected input contents into input content groups based on groups to which the participants belong; setting a representative flag on each of representative input contents selected from the respective input content groups; extracting the representative input contents and matching input contents, which match a predetermined extracting condition and are different from the representative input contents, from the collected input contents; and displaying a list of the representative input contents and the matching input contents on a display device that all the participants are able to view at a same time.

Group supporting apparatus for recognizing density of discussions and activity levels of individuals and related computer readable recording medium

An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. A cancer cell inhibitory drug containing at least a compound represented by general formula (1). 

Method of inhibiting cancer cell, method for detecting cancer cell, and system for detecting cancer cell

Provided is a novel probe for a biological specimen for labelling by itself and clearly visualizing one of a specific cell and a specific cell organ in a living body, the probe having excellent spectral characteristics and exhibiting excellent storage stability. The probe for a biological specimen contains, as an active agent, at least one kind of compound represented by a general formula (I). 

Probe for a biological specimen and labelling method and screening method using the probe

The invention provides a labeling composition for an intraocular tissue of a living individual, which specifically labels the intraocular tissue without need of an invasive operation such as exposure of an ocular tissue or injection of a staining agent into the ocular tissue or a nerve tissue linking to the ocular tissue, a method of noninvasively labeling an intraocular tissue of a living individual, and a screening method using the labeling composition for the intraocular tissues. The composition contains a compound capable of labeling at least a photoreceptor cell layer of a retina, wherein the compound is a staining compound having a particular structure as a partial structure thereof.

Labeling composition for intraocular tissue, labeling method of intraocular tissue, and screening method

A presenter selection support apparatus including: a display unit configured to display one or more opinions input from each of a plurality of terminals; a selection unit configured to select any one of opinions that belongs to a certain group based on a predetermined criterion when the certain group among at least one group formed by being classified from opinions displayed in the display unit is designated; and an instruction unit configured to instruct a terminal, in which an opinion other than the selected opinion is input, to display a screen in which each of a plurality of items related to relevancy to the selected opinion is selectable, wherein the predetermined criterion is a criterion used to specify any one terminal based on the number of times that one item among the plurality of items is selected in the past in each of the plurality of terminals.

Presenter selection support apparatus, presenter selection support system, and presenter selection support method

Growing community of inventors

Yokohama, Japan

Toshio Tanaka