Nippon Hypox Laboratories Inc.

Sawai Pharmaceutical Co., Ltd.

Other

Nippon Chemiphar Co., Ltd.

Sunstar Kabushiki Kaisha

Dainippon Ink and Chemicals, Incorporated

Kanebo, Limited

Teikoku Chemical Industry Co., Ltd.

Ltt Institute Co., Ltd.

Kuree Co., Ltd.

Kabushiki Kaisha Med-creat

E.p.d. Co., Ltd.

Toshio Satoh

Hitoshi Matsumoto

Hisao Kakegawa

Yasunori Niiro

Yoshiko Kato

Junji Yoshinaga

Yoshifumi Kanamoto

Juichi Riku

Mutsumi Muramatsu

Atsushi Tendo

Yasuo Kosaka

Hiroyasu Sekine

Kenji Hasegawa

Yutaka Mizushima

Goro Tsukamoto

Yasuhiro Katsuragi

Tetsuo Ebata

Masakazu Nakamura

Tokutaro Miki

Isao Nakajima

Yukio Yanagimoto

Tadami Shinuchi

Naoki Matsuda

Keiji Inouchi

Chitoshi Mori

Toshio Nakajima

Kakegawa Hisao

Yoshio Kikawa

Yoshiko Saiga

Kaname Kondo

Takashi Asai

Yukimitsu Masamoto

Hideki Miyataka

Yasunobu Kobayashi

The present invention relates to a process for producing a chitosan-containing soft capsule. The process includes the steps of rendering chitosan a powder; adding the chitosan powder, powder comprising an organic acid and a salt thereof, and an emulsifier to an oil or fat; stirring the resultant mixture so as to suspend the powders, to thereby obtain a gel-like stock; and feeding the gel-like stock and a gelatin solution for coating into an automated encapsulation machine, to effect encapsulation of the stock with gelatin.

Chitosan-containing soft capsule and process for producing the same

An antiallergic agent having leucotriene production inhibiting action and antihistaminic action, which can be orally administered is provided; the antiallergic agent comprises a hydroquinone derivative of general formula ##STR1## (wherein n represents an integer of 2-10).

Antiallergic agent having an anti-oxidant action

Processed material of bean curd refuse and method for the preparation

Novel hydroquinone derivatives of the formulae (I) and (II), ##STR1## wherein R.sup.1 is an alkyl group having 7 to 11 carbon atoms, ##STR2## wherein each of R.sup.2 to R.sup.5 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group provided that at least one of R.sup.2 to R.sup.5 is a lower alkyl group or a lower alkoxy group, and R.sup.6 is an alkyl group having a carbon chain of at least 2 carbon atoms. as compounds having antioxidant activity and tumor incidence inhibiting activity, and an antioxidant and a tumor incidence inhibitor containing, as an active ingredient, a hydroquinone derivative of the formula (III), ##STR3## wherein each of R.sup.7 to R.sup.10 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group, and R.sup.11 is an alkyl group having a carbon chain of at least 2 carbon atoms, and/or a salt thereof.

Hydroquinone derivative

Novel 3,4-dihydroxychalcone derivatives useful as a pharmaceutical material, and novel anti-inflammatory preparations. The 3,4-dihydroxychalcone derivatives are compounds of the formula [I], ##STR1## wherein X is a substituted phenyl group represented, e.g., by the formula (i), ##STR2## in which R.sup.1 is a hydrogen atom or an alkyl group and R.sup.2 is an alkyl group, an alkoxy group or an --OH group (excluding an OH-group in the 4-position) or salts thereof. The anti-inflammatory preparations contain one of the above 3,4-dihydroxychalcone derivatives as an active ingredient.

3,4-dihydroxychalcone derivatives

Food composition

Ascorbic acid derivative

This invention relates to a novel ascorbic acid derivative having excellent antioxidant action and a process for preparing the same. Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned ascorbic acid derivative or other known ascorbic acid derivatives.

Ascorbic acid derivative and use as antioxidant

Therapeutic agent for penal disorders

A powdery complex is obtained by combining a useful substance such as vitamin E and liquid fatty oil with albumin. This powdery complex has excellent storage stability and can keep the useful substance contained therein stably for a long time.

Useful substance-albumin complex

Pharmaceutical composition using albumin as a carrier and process for

This invention relates to a novel ascorbic acid derivative having excellent antioxidant action, particularly eliminating action on superoxides and a process for preparing the same. Furthermore, this invention also relates to a novel antioxidant comprising the afore-mentioned novel ascorbic acid derivative or other known ascorbic acid derivatives.

Ascorbic acid derivative and use as antioxidants

This invention relates to a novel ascorbic acid derivative having excellent antioxidant action, particularly eliminating action on superoxides and a process for preparing the same. Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned novel ascorbic acid derivative or other known ascorbic acid derivatives.

Compounds of the general formula: ##STR1## wherein R.sup.1 is heterocyclic group other than pyridyl and which is unsubstituted or substituted with lower alkyl or lower alkoxycarbonyl, R.sup.2 is hydrogen, halogen, or nitro, and R.sup.3 is carboxy group or its functional derivative, with the proviso that when R.sup.1 is an unsubstituted furyl, or furyl mono- or polysubstituted with alkyl and R.sup.2 is hydrogen, then R.sup.3 is functional derivative of carboxy and, where applicable, pharmaceutically acceptable salts thereof are hyaluronidase inhibitors and useful as anti-allergic agent.

Acrylamidobenzoic acid derivatives and their use

Growing community of inventors

Tokushima, Japan

Toshio Satoh