Daiichi Sankyo Company, Limited

Toshio Onoda

Hideki Kobayashi

Toshio Kaneko

Hideki Kubota

Nobuyuki Ohkawa

Masami Arai

Daisuke Takano

Naoki Terasaka

A compound represented by the general formula (I) or a pharmacologically acceptable salt thereof has an excellent LCAT-activating effect and is useful as an active ingredient in a therapeutic or prophylactic agent for arteriosclerosis, arteriosclerotic heart disease, coronary heart disease (including heart failure, myocardial infarction, angina pectoris, cardiac ischemia, cardiovascular disturbance, and restenosis caused by angiogenesis), cerebrovascular disease (including stroke and cerebral infarction), peripheral vascular disease (including diabetic vascular complications), dyslipidemia, hypo-HDL-cholesterolemia, or renal disease, particularly, an anti-arteriosclerotic agent, wherein R is an optionally substituted aryl group or an optionally substituted heteroaryl group. 

Piperidinylpyrazolopyridine derivative

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Yokohama, Japan

Toshio Onoda