Meiji Seika Kaisha, Ltd.

Meji Seika Kaisha Ltd.

Toshio Nishizuka

Yasuo Ohtsuka

Mami Kawaguchi

Takashi Shishikura

Sohjiro Shiokawa

Seiji Tsutsumi

Yumiko Okada

Kenichi Fushihara

Toyoaki Ishikura

Hideo Kitagawa

Sachiko Miyamoto

Hiromi Takata

Maki Shiobara

Shigeharu Inouye

Seiji Shibahara

Yasushi Murai

Tsuneo Okonogi

Hiroko Ogino

Masahiro Onodera

Koji Tsuchiya

Takako Iwasaki

Keiko Shito

Megumi Imai

Kenichi Fusihara

Yasuhiko Abat

The present invention relates to a compound of formula (1), wherein R, R, R, n, and X are as defined in the specification, and a process for producing the same. This compound is useful as an intermediate for the synthesis of compounds useful as pharmaceuticals or agricultural chemicals. 

4-alkyl-2-haloaniline derivatives and process for producing the same

Tricyclic triazolobenzazepine derivatives in the form or a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereon. The compounds are useful as antiallergic agents and exhibit excellent bioavailability. wherein Rrepresents hydrogen, OH, alkyl or phenyl alkyl, 

Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents

A process for preparing a compound represented by formula (IIa')wherein Q represents group (i) as defined in the specification and Rto R, R, R, and Rare as defined in the specification, by (1) reacting a compound represented by formula (V)wherein Rto Rand Rare as defined in the specification. with a compound represented by RRC&#x2550;O wherein Rand Rare as defined in the specification; (2) reacting the compound prepared in (1) with a compound represented by R&#x2014;C(&#x2550;O)&#x2014;Rwherein Rand Reach independently represent a chlorine atom, 4-nitrophenyl, or 1-imidazolyl; and (3) reacting the compound prepared in (2) with a compound represented by ROH wherein Ris as defined in the specification.

Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic

Tricyclic benzazepine compounds

The crystalline dihydrochloride of a specific cephalosporin derivative is stable to heat and retains its antibacterial activity even after storage over long periods at high temperature. The crystalline dihydrochloride can be obtained by removing protective groups from the cephalosporin derivative wherein the amino group and carboxy groups are protected and then crystallizing the cephalosporin derivative from a hydrochloric acid aqueous solution. The crystalline dihydrochloride is useful for pharmaceutical preparations.

Crystalline dihydrochloride of cephalosporin derivative and a method for

Growing community of inventors

Yokohama, Japan

Toshio Nishizuka