Shiseido Company, Limited

The General Hospital Corporation

Eisai Company, Limited

Koken Company, Limited

University School of Medicine

Toshio Nishiyama

Teruo Miyata

Satoshi Amano

Robert E Burgeson

Makoto Tsunenaga

Kenichi Tomita

Jiro Kishimoto

Masayasu Furuse

Naoki Tominaga

Kazumaro Furuse

Ritsuko Ehama

Eijiro Adachi

Nobuyuji Shioya

Toru Yamashita

Mutsumi Fukuyama

Keisuke Nakajima

Makoto Uzuka

Youichi Ohta

Shinichi Hirama

Robert Eugene Burgeson

The invention provides methods of evaluating a treatment for its effect on skin. The invention also provides non-human transgenic animals, e.g., mice, having a reporter gene coupled to a skin-metabolism promoter.

Method for evaluating a compound for its effect on skin

Disclosed are compositions for promoting the production of laminin 5 in epidermic cells which contain a lysophospholipid having a C fatty acid residue or a preparation derived from soybeans as an active ingredient and which can be used in the fields of cosmetics and dermatology. These compositions may be used especially for the purpose of potentiating the skin.

Agents promoting laminin production in skin cells

The use of laminin-5 to promote formation of basement membrane and to form skin equivalents and to improve grafting of keratinocyte sheets.

Laminin 5 and the formation of basement membrane structure

A hyaluronic acid-containing aqueous solution or aqueous dispersion of collagen having a pH of from about 6.5 to about 8.0 and an osmolality of from about 230 to about 320 mOsm/kgH.sub.2 O. The aqueous solution or the aqueous dispersion of collagen is useful as an agent for correction and reparation of a depressed part of or a void in soft tissue of mammals.

Hyaluronic acid-containing aqueous solution or aqueous dispersion of

A composition for reducing hair fall-out comprising a ubiquinone (coenzyme Q.sub.n) represented by the general formula: ##STR1## wherein n represents an integer of from 7 to 10. In addition to such a ubiquinone, the composition may contain a skin peripheral vasodilator drug, such as carpronium chloride, vitamin E nicotinate and benzyl nicotinate.

Composition for reducing natural hair fall-out

Growing community of inventors

Tokyo, Japan

Toshio Nishiyama