Wakamoto Pharmaceutical Co., Ltd.

Toshio Kuroda

Yoshihiro Tsuriya

Katsuya Ohata

Masahide Yamada

Touru Oguma

Hatsunori Toyofuku

Terumasa Hashimoto

Tooru Abe

Yukiyoshi Yanagihara

Hitoshi Aoki

Kenichi Edanami

Hiroshi Nagasawa

Shinji Kageyama

Koohei Nozawa

Yoshiaki Ogasawara

Shigekatsu Kohno

Toyokichi Yoshizawa

Takao Shida

5-(3-n-Butyloxalylaminophenyl) tetrazole having an excellent SRS-A release-inhibiting effect is used as an effective component for an anti-asthmatic agent, and a pharmaceutical preparation obtained by mixing the tetrazole with a specific dispersant such as polysorbate-80 in coexistence with a non-aqueous solvent shows high dissolubility and bioavailability.

Anti-asthmatic composition and process for preparing the same

New 1,3,4-thiadiazole derivatives of the general formula (I): ##STR1## wherein R.sub.1 represents a group of the formula: ##STR2## and R.sub.2 represents an amino, lower alkylamino, cyclohexylamino, benzoylamino, mercapto or lower alkylthio group, a process for the production of them and the use of the derivatives as antiulcer agents.

1,3,4-thiadiazole derivatives, process for the production thereof and

The following new isocarbostyryl derivatives represented by the general formula [I]: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl group, are provided, said derivatives having excellent angiotensin converting enzyme inhibitory activity with expectations therefore being as a hypotensor, and prepared by solvolysis of a compound of the following general formula [II]: ##STR2## wherein R.sub.1 is the same as defined above, R.sub.2 is an acyl group, and R.sub.3 is a hydrogen atom, an alkyl group or an aralkyl group.

1-Oxo-1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid derivatives

3-[3-(2-Haloethyl)-3-nitrosoureido]-3-deoxy-D-alloses are new, antitumor compounds having a far lower myelotoxicity as compared with conventional antitumor agents. They are obtained by treating 3-[3-(2-haloethyl)ureido]-3-deoxy-1,2,5,6,-di-O-isopropylidene-.alpha.-D-a llofuranoses with a nitrosating agent and then hydrolyzing the protective group in the presence of an acid.

D-Allose derivative and preparation method therefor

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Sagamihara, Japan

Toshio Kuroda