Matsushita Electric Industrial Co., Ltd.

Sumitomo Dainippon Pharma Co., Ltd.

The Kitasato Institute

Dainippon Sumitomo Pharma Co., Ltd.

Sumitomo Pharma Co., Ltd.

Boston Biomedical, Inc.

Toshio Kanai

Shingo Mizushima

Kohei Iwamoto

Toshiaki Sunazuka

Yohei Ikuma

Sachiko Koike

Shunichiro Uesugi

Keiji Adachi

Masafumi Komiya

Yoshihiko Noguchi

Hitoshi Suda

Takayuki Fukaya

Kuniko Urashima

Yuki Mizukami

Tokuo Nakatani

Takashi Nakajima

Yosuke Takanashi

Hitoshi Fujita

Toshinari Sugasawa

Shingo Tojo

Katsunori Tsuboi

Katsumi Kubota

Hidefumi Ino

Tomohiro Kodama

Provided is a novel compound that has an excellent &#x3b2;-lactamase inhibitory effect. More specifically, provided is a compound represented by formula (1a), (1b) or (11) having an excellent &#x3b2;-lactamase inhibitory effect or a pharmaceutically acceptable salt thereof. By using this compound either in combination with a &#x3b2;-lactam drug or alone, a useful preventive or therapeutic agent for bacterial infections is provided. Also provided are useful preventive or therapeutic agents for treating various diseases with the combined use of the aforesaid compound and &#x3b2;-lactam drugs.

Oxo-substituted compound

The present invention relates to a medicament for treating or preventing a disease involving Na channel, for example, neuropathic pain, nociceptive pain, inflammatory pain, small-fiber neuropathy, erythromelalgia, paroxysmal extreme pain disorder, dysuria, or multiple sclerosis, comprising a compound of formula (I) wherein R, R, R, and Rare hydrogen, halogen, cyano, Calkyl, Calkoxy, etc., provided that at least one of R, R, Rand Ris the above Caryl, Caryloxy, etc., Rand Rare hydrogen, Calkyl, Ccycloalkyl, etc., Ris hydrogen, Calkyl, Ccycloalkyl, etc., m is 0, 1, or 2, L is CRR, Rand Rare hydrogen, hydroxy group, Calkyl, Calkoxy, etc., or a pharmaceutically acceptable salt thereof. 

Deuterated benzimidazole compound and medical use thereof

The present invention provides a medicament for treating a disease involving Nav 1.7 such as neuropathic pain, nociceptive pain, inflammatory pain, small-fiber neuropathy, erythromelalgia, paroxysmal extreme pain disorder, dysuria, and multiple sclerosis, which comprises a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R, R, Rand Rare hydrogen, halogen, cyano, Calkyl, Calkoxy, or the like, provided that at least one of R, R, Rand Ris Caryl, Caryloxy, or the like, Rand Rare hydrogen, Calkyl, Ccycloalkyl, or the like, Ris hydrogen, Calkyl, Ccycloalkyl, or the like, m is 1, 2 or 3, L is CRR, and Rand Rare hydrogen, hydroxyl, Calkyl, Calkoxy, or the like.

Benzimidazole compound and medical use thereof

Benzimidazole compounds and medical uses thereof

Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, Ris optionally substituted heteroaryl etc.; Ris hydrogen etc.; Rand Rare each independently hydrogen etc., Ris the following group: (wherein Y is optionally substituted five membered heteroaryl etc., Ris optionally substituted aryl etc., Rand Rare each dependently hydrogen etc., and m is the integral 0 etc.) etc.; Ris hydrogen etc.; and Ris hydrogen etc. 

Heterocyclic substituted-3-heteroarylidenyl-2-indolinone derivative

Disclosed is a method for the prevention and/or treatment of a chronic obstructive pulmonary disease by administrating a 5-membered cyclic compound represented by the formula below: or a pharmaceutically acceptable salt of the compound or a prodrug of the compound or salt: wherein X represents an oxygen or sulfur atom; Rrepresents a hydrogen atom, a substituted or unsubstituted alkyl or the like; Rrepresents a hydrogen atom, a substituted or unsubstituted alkyl or the like; Yrepresents single bond, a substituted or unsubstituted alkylene or the like; the wavy line means an (E) or (Z) coordination; Rrepresents a hydrogen atom, a substituted or unsubstituted aryl or the like; Yrepresents a substituted or unsubstituted alkylene or an alkenylene; Rrepresents a hydrogen atom, a substituted or unsubstituted alkanoyl or the like; and Rrepresents a hydrogen atom or a substituted or unsubstituted alkyl.

Therapeutic agent for chronic obstructive pulmonary disease

A reproducing apparatus according to the present invention includes: a first storage including a changer for housing a plurality of storage media and a drive for reading out data from first and second target storage media selected from the storage media in that order; a second storage; a data processing unit for presenting the data stored on the first and second target storage media; and a controller for controlling the changer, the drive, the data processing unit and the second storage. Before the data processing unit starts to present the data stored on the first and second target storage media, the controller controls the first storage to read out at least part of the data stored on one of the first and second target storage media as bridging data and controls the second storage to store the read bridging data. When the data processing unit starts to present the data stored on the first and second target storage media, the controller controls the second storage to supply the bridging data to the data processing unit during a period in which reading the data stored on the first and second target storage media is discontinuous because of exchange of the first target storage medium for the second target storage medium, so as to present the data stored on the first and second target storage media continuously.

Reproducing apparatus, recording apparatus and recording/reproducing apparatus

A power supply circuit for a CRT display device includes a low-voltage power supply switching circuit for supplying power to a horizontal oscillation circuit of the CRT display device, and a high-voltage power supply switching circuit for supplying power to high-voltage circuits of the CRT display device. The low-voltage power supply switching circuit includes an oscillator and a switching transistor. The oscillator is triggered by an output of the horizontal oscillation circuit, and the conductive state of the switching transistor is controlled according to an output of the oscillator. The high-voltage power supply switching circuit includes a switching transistor. The conductive state of the switching transistor of the high-voltage power supply switching circuit is controlled according to an output of the low-voltage power supply switching circuit. As such, the switching operations of the low-voltage and high-voltage power supply switching circuits is carried out at a same frequency and in synchronism with the output of the horizontal oscillation circuit.

CRT power supply apparatus having synchronized high and low voltage

Synchronizing signal extracting apparatus

A clamping circuit of a high definition CRT display which is adapted to feed the picture signals to the cathode of the cathode-ray tube through a coupling capacitor is connected to the above described cathode, and the above described pulse clamping circuit is operated during the picture blanking period for charging the coupling capacitor so as to change the DC voltage of the cathode. A reference voltage source which conforms to the electrical potential of the black level of the above described picture signal is provided, the above described reference voltage source is connected to the picture signal output line during the picture blanking period so as to reduce the output impedance of the picture output circuit during the same period to correctly reproduce the brightness in spite of the picture signals.

Black level clamping circuit including video output stage

A picture display apparatus for displaying a picture by using a composite signal including tri-state binary synchronizing signals. A first horizontal synchonizing signal comprising a positive-polarity bilevel (the two-state) signal is generated by detecting a negative-polarity peak portion of an input composite picture signal to accomplish the horizontal synchronization of a picture by use of the first horizontal synchronizing signal whereby when the horizontal synchronization is stabilized, an output pulse produced from the first horizontal synchronizing signal is utilized to extract the tri-state binary horizontal synchronizing signal from the composite picture signal during the time of the output pulse thereby accomplishing horizontal synchronization of the picture by the tri-state binary horizontal synchronizing signal in the stable condition.

Picture display apparatus

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Osaka, Japan

Toshio Kanai