Fujisawa Pharmaceutical Company, Ltd.

Juridical Foundation the Chemo-sero-therapeutic Research Institute

Jcr Pharmaceuticals Co., Ltd.

Toshio Hattori

Kiyoshi Takatsuki

Hiroshi Kayakiri

Masanori Okamoto

Sachio Tokiyoshi

Katsuya Nakamura

Yasuyuki Eda

Yoshiko Yokota

Yoshikazu Yuki

Kouichi Shiosaki

Tsutomu Kaizu

Kiyoshi Osatomi

Shuzo Matsushita

Yohsuke Maeda

A murine monoclonal antibody which specifically binds to a glycoprotein antigen having a molecular weight of about 12.times.10.sup.4 daltons (gp120) present in the envelope of human T-lymphotropic virus III.sub.MN (HTLV-III.sub.MN) and capable of neutralizing the HTLV-III.sub.MN as determined by in vitro inhibition of syncytium formation but does not bind to other HTLV-III strains, or antigen-binding fragments, which is useful for prophylaxis, treatment and diagnosis of AIDS.

HIV monoclonal antibody specific for the HTLV-III.sub.mn gp120 envelope

Human urine trypsin inhibitor is provided as an agent for treating acquired immunodeficiency syndrome (AIDS), preventing the infection with AIDS or preventing the onset of AIDS after such infection. It can be administered intravenously for the treatment and externally for the prevention.

Agent for treating or preventing AIDS using human urine trypsin inhibitor

Pyrroline compounds of the formulae (I) and (II) are effective in the treatment of retroviral infection and lymphadenopathy. ##STR1##

Antiretroviral agent, method of use thereas, and method of preparation

Growing community of inventors

Kumamoto, Japan

Toshio Hattori