Shionogi Company Limited

Teikoku Hormone Mfg. Co., Ltd.

Toshio Fujishita

Teruyuki Ishiba

Kentaro Hirai

Tomokazu Yoshinaga

Shigeru Matsutani

Akihiko Sato

Itsuo Makino

Koichi Otani

Masami Eigyo

Akira Matsushita

Hirohiko Sugimoto

Masami Doteuchi

Susumu Takada

Takashi Sasatani

Takashi Kawasuji

Kaoru Seno

Yukio Tada

Toshiyuki Akiyama

Makoto Kawai

Masahiro Fuji

Shozo Takechi

Yasuhiko Kanda

Minako Mikamiyama

Yoshiyuki Matsuo

Kenji Abe

Koichi Nishi

Ryuichi Kiyama

Kentato Hirai

Hiroshiko Sugimoto

Masami Doeteuchi

The present invention provides an integrase inhibitor. The inventors have found the following compound of formula (I) possessing an integrase inhibitory activity.  

Antiviral agent

This invention provides compounds having antiviral activities especially inhibiting activity for influenza virus, more preferably provides substituted 3-hydroxy-4-pyridone derivatives having cap-dependent endonuclease inhibitory activity.

Substituted 3-hydroxy-4-pyridone derivative

A compound represented by the formula (Ia) (wherein R1, R2, and R3 to R5 are the same as defined in the description), a prodrug thereof, a pharmaceutically acceptable salt thereof, or solvate thereof. The compounds are useful in the prevention of or treatment for diseases relating to NAD(P)H.

Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same

A compound of the formula (I):wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is &#x2014;COORwherein Ris hydrogen or ester residue, &#x2014;CONRRwherein Rand Reach is independently hydrogen or amide residue, optionally substituted aryl or optionally substituted heteroaryl; and Ais optionally substituted heteroaryl; provided that a compound wherein Y and/or Ais optionally substituted indol-3-yl is excluded, a tautomer, a prodrug, a pharmaceutically acceptable salt or a hydrate thereof has an inhibitory activity against an integrase.

Heteroaromatic derivatives having an inhibitory activity against HIV integrase

Compounds having anti-hepatitis C virus effect

Indole derivatives having an antiviral activity

Aromatic heterocycle compounds having HIV integrase inhibiting activities

Indole derivatives with antiviral activity

2-Substituted carbonylimidazo[4,5-c]quinolines of formula: ##STR1## having a high affinity for benzodiazepin receptor and showing an excellent psychostimulating action orally at a dose of 0.1-500 mg are provided through several routes.

2-substituted carbonylimidazo[4,5-c]quinolines

A compound of the formula: ##STR1## (wherein R is phenyl optionally substituted by one or two members selected from the group consisting of trifluoromethyl, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkylthio, nitro, amino C.sub.1 -C.sub.5 alkanoylamino and C.sub.1 -C.sub.5 alkoxycarbonyl or 5- or 6-membered heterocyclic group optionally substituted by one or two members selected from the group consisting of halogen, C.sub.1 -C.sub.5 alkyl and C.sub.1 -C.sub.5 alkoxy,

Condensed imidazopyridine derivatives useful as psychotropic agents

An aminoalkylbenzene derivative of the formula: ##STR1## [wherein A is oxygen or sulfur;

Aminoalkylbenzene derivatives

Substituted aminoalkylbenzene type lower acylamides

Pyridinecarbonamido-oxy or thio

Growing community of inventors

Osaka, Japan

Toshio Fujishita