Hayashibara Co., Ltd.

Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo

Toshio Ariyasu

Hitoshi Mitsuzumi

Shuji Nakamura

Kunzo Orita

Koichi Nishi

Akira Kawashima

Akiko Yasuda

Mitsuyuki Kambe

Shigeharu Fukuda

Tsunetaka Ohta

Tatsuya Ishihara

Masaki Miyake

Akiko Miyake

Harumi Ariyasu

Masahiro Fujimoto

Chie Ushio

Tohru Kayano

Masaki Kono

Yutaka Akagi

Motoyuki Suzuki

The present invention aims to provide a novel glycosyl hesperetin, which is significantly reduced in miscellaneous tastes characteristic of conventional products containing glycosyl hesperetin, and a method for producing the same and uses thereof; and the objects are solved by providing a glycosyl hesperetin which comprises glycosyl hesperetin in an amount of 90% or more by mass but less than 100% by mass, on a dry solid basis, but it does not substantially contain furfural, and a method for producing the same and uses thereof.

Glycosyl hesperetin and process for producing the same and uses thereof

An object of the present invention is to provide a particulate composition containing crystalline &#x3b1;,&#x3b1;-trehalose dihydrate, having an advantageous emulsifying ability. The above object is solved by providing a particulate composition comprising crystalline &#x3b1;,&#x3b1;-trehalose dihydrate, which consists of particles containing &#x3b1;,&#x3b1;-trehalose and maltose and/or maltotriose, wherein said particulate composition contains &#x3b1;,&#x3b1;-trehalose in an amount of 70% by weight or higher but 90% by weight or lower, on a dry solid basis; and maltose and/or maltotriose in a total amount of 3% by weight or higher, on a dry solid basis; and has a degree of crystallinity for crystalline &#x3b1;,&#x3b1;-trehalose dihydrate of 25% or higher but less than 90%, when calculated based on its powder X-ray diffraction profile.

Particulate composition comprising crystalline alpha, alpha-trehalose dihydrate, its preparation and uses

[Object] The present invention has an object to provide an external dermal agent for reducing skin yellowness already generated in the skin. [Means to Attain the Object] The above object is solved by providing an external dermal agent for reducing skin yellowness already generated in the skin, which contains hesperetin and/or glycosyl hesperetin as an effective ingredient(s).

External dermal agent for reducing yellowish dullness

The present invention has the first object to provide a monoclonal antibody specific to interferon &#x3b1; subtype &#x3b1;8 (IFN&#x3b1;8) and its mutant proteins, the second object to provide a hybridoma capable of producing the monoclonal antibody, the third object to provide a method for detecting the IFN&#x3b1;8 and its mutant proteins by the monoclonal antibody, the fourth object to provide a method for purifying the IFN&#x3b1;8 and its mutant proteins by the monoclonal antibody, and the fifth object to provide a therapeutic agent for treating diseases whose onsets or exacerbation are related with IFN&#x3b1;8. The present invention solves the above objects by providing a monoclonal antibody specific to IFN&#x3b1;8 and its mutant proteins, a hybridoma capable of producing the monoclonal antibody, a method for detecting the IFN&#x3b1;8 and its mutant proteins by immunoreaction using the monoclonal antibody, a method for purifying the IFN&#x3b1;8 and its mutant proteins using the monoclonal antibody, and a therapeutic agent for treating diseases whose onsets or exacerbation are related with IFN&#x3b1;8, which contains the monoclonal antibody as an effective ingredient.

Monoclonal antibodies specific for human interferon-alpha subtype alpha 8

Disclosed are a novel hedgehog protein, i.e., a Desert hedgehog protein of human origin including mature and precursor forms, a DNA encoding the protein, a monoclonal antibody recognizing the protein, a process for producing the protein, and a method for detecting the protein. The hedgehog protein is useful in establishment of hybridomas which produce antibodies recognizing the protein, and the monoclonal antibody is useful in detection and purification of the protein. The hedgehog protein, DNA, and monoclonal antibody of this invention have efficacy in elucidation of hereditary morphological abnormalities in humans to establish their treatments and diagnoses.

Human desert hedgehog protein

Hedgehog protein

Growing community of inventors

Okayama, Japan

Toshio Ariyasu