Shimadzu Corporation

Toshinobu Yanagisawa

Yasuhiro Mito

Kenichi Mishima

Etsuho Kamata

Hiroshi Miura

Yuki Ishikawa

Takeshi Yoshida

Hiroaki Kozawa

Yuji Katsuyama

Keisuke Munetaka

Shingo Takimoto

Kanta Horie

A waveform processing assistance device includes an acquirer that acquires a plurality of waveform data obtained by an analysis of a sample, a selector that selects reference data among the waveform data, an extractor that extracts correct answer peaks and correct answer data from the reference data a determiner that determines each processing section including a correct answer peak and each parameter initial value, a waveform processor that performs waveform processing in each determined processing section based on each parameter initial value, an adjuster that generates a parameter adjustment value at which a waveform processing result obtained in each processing section matches or approximates corresponding correct answer data, and a program creator that creates a waveform processing execution program that includes an instruction to execute waveform processing using the parameter adjustment value in each processing section.

Waveform processing assistance device and waveform processing assistance method

A data processing device that processes three-dimensional data having time, intensity, and wavelength collected from a sample serving as a measurement target includes: a chromatogram generator configured to generate a chromatogram from the three-dimensional data; a target peak determiner configured to determine a target peak from peaks appearing on the chromatogram; a time point specifier configured to specify a time point at which the size of a spectrum matches the size of a reference spectrum from a time range during which the target peak appears in the three-dimensional data; and a target spectrum generator configured to extract data at the time point from the three-dimensional data, thereby generating a spectrum at the time point. With this configuration, a spectrum that is not affected by distortion, saturation, or noise can be readily and reliably obtained from the three-dimensional data obtained through sample analysis.

Data processing device

A chromatogram data processing system having an impurity detector including a differential chromatogram creator, a purity curve creator and a determiner. The differential chromatogram creator calculates a differential coefficient of an absorbance spectrum with respect to wavelength at a local maximum or local minimum absorption wavelength of the target component, and creates a differential chromatogram which shows a temporal change of the differential coefficient. The purity curve creator creates a purity curve which shows a temporal change of the difference between the degree of similarity of a spectrum on the target peak to a reference spectrum and a threshold of the degree of similarity which is determined taking into account the influence of noise components. The differential chromatogram and the purity curve are displayed on a display unit in a superposed form on a wavelength chromatogram created by a wavelength chromatogram creator.

Chromatogram data processing system

A system for creating a chromatogram based on a temporal change of a spectrum obtained within a predetermined wavelength range including a target wavelength, the system including a post-correction chromatogram display section for displaying a post-correction chromatogram obtained by multiplying a chromatogram at the designated wavelength by a sensitivity factor obtained by dividing the intensity of the designated-time spectrum at the target wavelength by the intensity of the designated-time spectrum at the designated wavelength, and for changing the display to a post-correction chromatogram corresponding to the latest values of the designated time point and the designated wavelength when one or both of the designated time point and the designated wavelength are changed.

Data processing system and data processing method for chromatograph

Provided is a systemfor monitoring an operating status of a chromatograph to determine whether or not an abnormality due to an external condition independent of the characteristics of a sample being analyzed is present in the operating status of the chromatograph. This system includes: an external-condition measurement device (pressure sensorA, column oven thermometerB and room temperature thermometerC) for performing a time-series of measurement of the external condition and for obtaining a series of external-condition-related data; an index value calculatorfor calculating an index value based on the series of the external-condition-related data obtained through an analysis; and an index value storage (data storage) for storing the index value for the analysis, with the index value being linked with an analysis data obtained through the analysis.

System for monitoring operating status of chromatograph to determine whether the chromatograph is operating normally or abnormally

Regarding a chromatogram data processing device configured to process three-dimensional chromatogram data collected on a target sample in which dimensions are made up of time, wavelength, and absorbance, and the chromatogram data processing device includes a differential spectrum generating means configured to generate a differential spectrum that represents a change in a wavelength differential coefficient, which is a differential coefficient in a wavelength direction in a predetermined wavelength range, based on the three-dimensional chromatogram data, with respect to an absorbance spectrum representing a relation of the wavelength and the absorbance at each time in an entire temporal range or a predetermined temporal range, and a determination means configured to determine whether or not one or plural other components are included in a peak of a target component, based on a temporal change in a waveform of the differential spectrum, so that the determination on whether or not a target sample includes impurities can be performed with high accuracy without the requirement of complicated computation processing.

Chromatogram data processing device and processing method

A data processing system for a chromatograph has an impurity detector including a differential chromatogram creator and a determining section. The differential chromatogram creator calculates a wavelength differential coefficient by differentiating an absorbance spectrum with respect to the wavelength at each point in time of the measurement and creates a differential chromatogram which shows a temporal change in the wavelength differential coefficient. Based on a shape of the thus created differential chromatogram, the determining section determines whether or not a peak of a target component contains an impurity. By this method, whether or not the peak of the target component contains an impurity can be determined with high accuracy, without requiring complex calculations.

System and method for processing chromatogram data

A data processing system including a sensitivity coefficient holder for holding a value R of a sensitivity coefficient for a wavelength &#x3bb;belonging to one peak in a spectrum of a first component and a second wavelength &#x3bb;belonging to the same peak and having a lower intensity than &#x3bb;, the value R defined using the ratio of the peak areas or similar information of two chromatograms respectively obtained at the two wavelengths; a chromatographic detector for spectroscopically analyzing sample components exiting from a component-separating column and for measuring an intensity at the second wavelength &#x3bb;of the spectrum of the first component and an intensity at a wavelength &#x3bb;of a spectrum of a second component at each point in time; and a concentration ratio calculator for calculating the ratio of concentration between the first component and the second component.

There are provided a data processing device for chromatograph and a data processing method for chromatograph which allow a peak to be desirably checked. A peak (correction target peak (P)) whose intensity exceeds a predetermined threshold in a chromatogram at a target wavelength (&#x3bb;) is corrected based on correction reference values (height (H) and area (A) of a peak (P)) and a sensitivity coefficient (R=I/I), and the chromatogram after correction is displayed or printed. Therefore, even if the correction target peak (P) is saturated, display or printing may be performed in a state where correction has been performed so that the chromatogram at the peak (P) is not cut off in the middle. Accordingly, at the time of display or printing of the chromatogram, a fine peak may be prevented from becoming too small, and also the correction target peak (P) may be prevented from being cut off in the middle, and thus the peaks may be desirably checked.

Data processing device for chromatograph and data processing method for chromatograph

A preparative separation chromatograph system having a column for temporally separating components in a sample and for discharging an eluate fluid with the components, a detector for obtaining an absorbance spectrum of the eluate fluid, and a fraction collector for continuously creating a chromatogram. The system further includes: a peak section determiner; a differential value determiner for calculating a differential spectrum value and for determining whether or not the absolute value of the differential spectrum value is equal to or less than a predetermined value; and a fraction collector controller for controlling the fraction collector so as to fractionate the eluate fluid during a period of time for which it is determined that the chromatogram peak of the target component is present and for which it is also determined the absolute value of the differential spectrum value is equal to or less than the predetermined value.

Preparative separation chromatograph system

A data processing system for a chromatograph including a standard sample data storage section; a standard sample sensitivity factor calculator; a post-correction standard sample chromatogram strength calculator; a specific designated retention time and specific designated wavelength setter; a measurement sample data storage section; a measurement sample sensitivity factor calculator; and a post-correction measurement sample chromatogram creator.

Data processing system and method for chromatograph

In an analyzing system including a commanding unit for sending a command and an executing unit for executing a processing upon receiving the command, a processing instruction may not be executed at the right time due to a heavy traffic of information and other factors. In order to solve this problem, in a preparative separation systemaccording to the present invention, a PCprovides the execution time for starting/finishing the fractionation processing to a controller. Therefore, even in the case where the time of the PCand that of the controllerare not synchronized, the controllercan accurately set the execution time for starting/finishing the fractionation in a preparative separation unit. A pipingmay be placed so that the traveling time of sample components is sufficiently larger than the delay time of signals due to the signal transfer lag and other reasons. This can absorb the delay time, allowing the units to cooperate with each other at a correct timing.

Analyzing system

A data processor composed of: a main body including a CPU, a keyboard provided at the top of the main body, a pair of sliding rails provided at both sides of the keyboard, a pair of sliders each for sliding on one of the sliding rails, a lid pivotably connected to the sliders and a display panel attached on one face of the lid. When the data processor is not used, the sliders are moved to the rear end, and the lid is tilted down, whereby the keyboard is covered by the lid. When the keyboard is used, the lid is raised up with the sliders at the rear end. After the keyboard operation is finished, the sliders are (and the lid is) moved to the front end. When the lid is tilted down with the sliders at the front end, the data processor becomes compact and the display panel can be seen from the outside. Since the keyboard is covered by the lid, the keys are secured from mistouches, and the operator can see the display without bending low.

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Kyoto, Japan

Toshinobu Yanagisawa