Fuji Photo Film Company, Limited

Dana-farber-cancer Institute Inc.

Yuji Mihara

Toshinao Ukai

Haruo Takei

Kazunobu Katoh

Masaki Okazaki

Keizo Koya

Hisashi Okada

Takao Masuda

Morio Yagihara

Tadashi Ikeda

Yoshio Inagaki

Keiichi Adachi

Yoshihiro Takagi

Nobuaki Inoue

Ichizo Toya

Kunio Ishigaki

Mitsuo Saitou

Syunichi Kondo

Akihiko Ikegawa

Masayuki Kawakami

Yasuhiro Noguchi

Masahiro Okada

Kiyohiko Yamamuro

Kenji Sashihara

Shigeru Ohno

Seiji Suzuki

Hideo Sato

Koki Nakamura

Akira Sato

Tadahisa Sato

Toshio Kawagishi

Akihiro Matsufuji

Tadao Shishido

Masakazu Yoneyama

Seiiti Kubodera

Toshiyuki Watanabe

Yasuo Okamoto

Shoji Ishiguro

Naoyasu Deguchi

Akira Umehara

Lan Bo Chen

Sadanobu Shuto

Satoru Sawada

Satoshi Nagaoka

Munehisa Fujita

Kimitaka Kameoka

Nobuyoshi Sekikawa

Yuichi Ohashi

Shunichi Aida

Osami Tanabe

Tetunori Matushita

Gouichi Hayashi

Naomi Saeki

Sadao Kamei

Junji Miyata

Hatsumi Tanemura

Kazuhiro Shirasu

Sadanobu Syuto

A pharmaceutical composition for treatment of cancer in an animal comprising: (A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds represented by the General Formula (I). ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents an atomic group necessary to form a 5- or 6-membered ring; R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, each represents an alkyl group or an aryl group; L.sub.1 and L.sub.2 each represents a methine group or a substituted methine group; X represents a pharmaceutically acceptable anion; k represents a number necessary for electrical charge balance; n represents 0 or 1; and (B) a pharmaceutically acceptable carrier or diluent.

Composition and method for treating cancer

A methine compound represented by the following formula (I): ##STR1## wherein Z.sub.1 and Z.sub.2 each represent a non-metallic atomic group necessitated for forming a five-membered or six-membered, nitrogen-containing heterocyclic ring, R.sub.1 and R.sub.2 each represent an alkyl group, X represents an inorganic anion, k represents a number necessitated for adjusting the electric charge of the molecule to zero, and n represents 0 or 1; with the proviso that when n is 1, the five-membered or six-membered, nitrogen-containing heterocyclic ring formed by Z.sub.2 is cationic, k is not zero and X represents chloride ion. The compound is useful as a spectral sensitizing dye and an antitumor agent.

Water-soluble methine derivatives of thiazole

A water-soluble methine compound represented by the following general formula (I): ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents a non-metallic atomic group required for forming a 5-membered or 6-membered nitrogen-containing heterocyclic ring; R.sub.1 and R.sub.2, which may be the same or different, each represents an alkyl group; Q.sub.1 and Q.sub.2 each represents an atomic group required, in combination, for forming a 4-thiazolidinone ring, a 5-thiazolidinone ring, a 4-imidazolidinone ring, a 4-oxazolidinone ring, a 5-oxazolidinone ring, a 5-imidazolidinone ring or a 4-dithiolanone ring; L.sub.1, L.sub.2, L.sub.3, L.sub.4 and L.sub.5, which may be the same or different, each represents a methine group; R represents a hydrogen atom, an alkyl group, an aryl group or a heterocyclic group; m represents 1 or 2; i and h each represents 0 or 1; l represents 1 or 2; and j and k each represents 0, 1, 2 or 3. A photographic silver halide emulsion containing said methine compound added in the form of an aqueous solution is also disclosed.

Water-soluble methine compounds useful in photographic silver halide

A photopolymerizable composition comprises: (i) a polymerizable compound carrying an addition-polymerizable unsaturated bond; (ii) a methine compound; (iii) at least one compound selected from the group consisting of: (a) compounds having carbon-halogen bonds, (b) aromatic onium salts, (c) organic peroxides, (d) thio compounds, (e) hexaaryl-biimidazoles, (f) ketooxime esters, and (g) compounds represented by the following general formula (III): ##STR1## wherein R.sup.6, R.sup.7, R.sup.8 and R.sup.9 may be the same or different and each represents a substituted or unsubstituted alkyl, aryl, alkenyl, alkynyl or heterocyclic group, provided that at least two of R.sup.6, R.sup.7, R.sup.8 and R.sup.9 may be bonded together to form a ring structure and that at least one of them represents an alkyl group; and Z.sup.+ represents an alkali metal cation or a quaternary ammonium cation. The composition has a high sensitivity to a wide range of actinic light rays extending from ultraviolet to visible light.

Photopolymerizable composition

Methine compounds represented by the following general formula (Ia) or (Ib); ##STR1## wherein CYA represents atoms having a cyanine chromogen structure, MER represents atoms having a merocyanine chromogen structure, L represents a divalent linkage group composed of an atom or atoms containing at least one of a carbon atom, a nitrogen atom, a sulfur atom and an oxygen atom, Het represents a group containing a 5- to 7-membered hetero ring containing at least one nitrogen atom, l.sub.1 represents 1 or 2, l.sub.2 represents 0 or 1, and l.sub.3 represents 1, 2 or 3. Methine dyes using same are also disclosed.

Methine compounds and methine dyes

A silver halide photographic emulsion is disclosed, comprising a combination of at least one infrared sensitizing dye represented by formula (Ia) or (Ib) and at least one compound represented by formula (IIa) or (IIb): ##STR1## wherein each of the variables is as defined in the specification.

Silver halide photographic emulsion

A process or the preparation of a silver halide photographic emulsion is provided which comprises the addition of at least one pendant type spectral sensitizing dye containing as a substituent a compound having the effect of inhibiting fog at any time after the formation of silver halide grains, but before the completion of the chemical ripening process. In a preferred embodiment, the addition of said pendant type spectral sensitizing dyes is effected at any time after the formation of silver halide grains, but before former one second of the total time of the chemical ripening process. The pendant type spectral sensitizing dyes are compounds represented by the general formula (III) or (IV): ##STR1## wherein SSD represents a sensitizing dye portion; AF represents a compound portion containing a saturated or unsaturated 5- to 7-membered ring containing at least one nitrogen atom; L.sup.1 represents a divalent connecting group containing at least one of C, N, S and O; L.sup.2 has the same meaning at L.sup.1 and does not connect SSD and AF; l.sup.1, l.sup.2 and l.sup.3 each represents an integer 1 to 3, l.sup.2 being equal to l.sup.1 or l.sup.3 ; l.sup.4 represents an integer 0 to 3; and l.sup.5 represents an integer 0 or 1, with the proviso that when there is a plurality of L.sup.1 's, L.sup.2 's, SSD's or AF's, they may be the same or different and that when none of L.sup.2 's adjacent to l.sup.5 connect SSD and AF, l.sup.5 represents 0.

Process for the preparation of silver halide photographic emulsion

A silver halide photographic material is disclosed, comprising a support having thereon an emulsion layer comprising a dispersion medium, silver halide grains, and a pendant type sensitizing dye, wherein said pendant type sensitizing dye is a compound comprising a sensitizing dye and an antifoggant, each of which may have substituent groups and wherein said sensitizing dye and antifoggant are organochemically bonded.

Silver halide photographic materials

A silver halide photographic material comprising a support having thereon at least one silver halide emulsion layer, said emulsion layer or at least one of other hydrophilic colloid layers containing a compound represented by formula (I):

Silver halide photographic material and method for forming super high

A silver halide photographic material capable of providing very high contrast image and having improved safelight safety is described, which comprises a support having thereon at least one silver halide emulsion layer, and containing in the silver halide emulsion layer or another hydrophilic colloid layer (i) a compound represented by formula (I) ##STR1## wherein PWR represents a group capable of releasing ##STR2## upon being reduced; Time represents a group capable of releasing LA after being released from PWR, t is 0 or 1; and LA represents a group having an absorption maximum in the wavelength region longer than 310 nm, (ii) a hydrazine derivative, and (iii) at least one compound represented by formulae (IX) and (X) ##STR3## wherein R.sup.91, R.sup.92, R.sup.93, and R.sup.94, which may be the same or different, each represents hydrogen, an alkyl group, an aryl group, an amino group, a hydroxyl group, an alkoxy group, an alkylthio group, a carbamoyl group, a halogen atom, a cyano group, a carboxyl group, an alkoxycarbonyl group or a heterocyclic group and R.sup.91 and R.sup.92 or R.sup.92 and R.sup.93 may be linked to form a 5- or 6-membered ring; provided that at least one of R.sup.91 and R.sup.93 represents a hydroxyl group.

Silver halide photographic material containing a compound capable of

A silver halide photographic light-sensitive material, in which a highly immobile novel arylidene bis type of dye which selectively dyes a specific layer and does not diffuse into other layers is incorporated in a hydrophilic colloidal layer. The dye used in this light-sensitive material can be easily removed upon photographic processing, and does not adversely affect photographic properties, particularly spectral sensitization, of the photographic emulsions.

Silver halide photographic light-sensitive element containing water

A near infrared absorbing composition is disclosed, containing at least one compound represented by general formula (I), having its absorption maxima at wavelengths of 720 nm or more: ##STR1## wherein R.sup.1 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group; R.sup.2 and R.sup.5, which may be the same or different, each represents a hydrogen atom or a group capable of substituting a hydrogen atom; R.sup.3 and R.sup.4, which may be the same or different, each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted alkoxy group or a substituted or unsubstituted alkyl group with the proviso that they do not simultaneously represent hydrogen atoms; and R.sup.6 and R.sup.7, which may be the same or different, each represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, an acyl group or a sulfonyl group, or R.sup.6 and R.sup.7 may be taken together to form a 5- or 6-membered ring.

Near infrared absorbing composition

A silver halide photographic material comprising a support having thereon at least one silver halide light-sensitive emulsion layer, wherein at least one compound represented by the formula (I) is present in said silver halide emulsion layer or at least one other hydrophilic colloid layer of said material:

Silver halide photographic material

A superhigh contrast negative type silver halide photographic material, comprising a support having provided thereon at least one silver halide emulsion layer, wherein the emulsion layer or at least one other hydrophilic colloid layer contains at least one hydrazine derivative and at least one organic desensitizer having at least one water-soluble group or alkali-dissociative group. The material has a reduced sensitivity suitable for processing in a bright room while enjoying the effect of the hydrazine derivative to increase contrast.

Superhigh contrast negative type silver halide photographic material

Growing community of inventors

Kanagawa, Japan

Toshinao Ukai