Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kogyo Kabushiki Kaisha

Toshimitsu Takiguchi

Yutaka Saito

Masami Okabe

Hirofumi Nakano

Chikara Murakata

Shiro Akinaga

Hiromitsu Saito

Satoru Nagamura

Keiichi Takahashi

Mitsunobu Hara

Shigeo Katsumata

Akira Mihara

Mitsutaka Kino

Yoji Ikuina

Hidenori Aoki

A staurosporine derivative with anti-cancer activity and anti-bacterial activity is produced by acidifying a solution containing staurosporine to isomerize staurosporine to its desired derivative, whereby the derivative is recovered from the acidified solution.

Production of staurosporine derivative using acid isomerization

Disclosed is a process for producing a staurosporine derivative represented by Formula (I): Q is defined as in specification: ##STR1## The staurosporine derivative (I-1) possesses selective protein kinase C-inhibitory and cell growth-inhibiting activities, and platelet-increasing activity.

Process for producing staurosporine derivatives

Compounds UCF1 and derivatives thereof exhibit anti-bacterial and anti-tumor activities and may be used for the preparation of anti-bacterial and anti-tumor agents. Compounds UCF1 may be produced by fermentation of a microorganism of the genus Streptomyces capable of producing compounds UCF1, preferably Streptomyces sp. UOF1 (FERM BP-2844) and recovering the desired compounds from the cultured broth. The compounds UCF1 have the formula ##STR1## wherein R represents either ##STR2## The compounds may be oxidized to obtain derivatives of formula ##STR3## which exhibit similar pharmacological activities.

Epoxycyclohexenone amides with antibacterial activity

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Shizuoka, Japan

Toshimitsu Takiguchi