Pola Chemical Industries, Inc.

Pola Chemical Industries Inc., Japan

Toshimitsu Suzuki

Masayuki Yuasa

Takuji Nakashima

Yukio Kawazu

Yoshiyuki Miyata

Toshiro Majima

Masakazu Sakaguchi

Akira Nozawa

Tomoyuki Mori

Takao Itoh

Hiroyuki Takimoto

Kouji Yokoyama

Akira Suzuki

Takao Ito

Azuma Nishio

Tsutomu Takeuchi

Seiki Kobayashi

Hiroyuki Nakano

Kazuo Nabeta

Takuo Shiga

Yuichi Yokomizo

Amine derivatives

Novel amine derivatives having an excellent antimycotic effect represented by general formula (1) below and salts thereof are provided.

Antifungal amine derivatives and processing for producing the same

This invention relates to compounds represented by the following formula (1): ##STR1## wherein R.sup.1 represents a substituted or unsubstituted phenyl group, R.sup.2 represents a substituted or unsubstituted phenylene group, R.sup.3 represents a substituted or unsubstituted phenyl group or an aliphatic hydrocarbon group containing at least four .pi. electrons, R.sup.4 represents an alkyl group having 1 to 4 carbon atoms, and m and n individually represent integers of from 1 to 4, or salts thereof, and also to compositions containing the same. These compounds have antifungal activities and are useful as drugs.

Antifungal agents

This invention relates to compounds represented by the following formula (1): ##STR1## wherein R.sup.1 represents a substituted or unsubstituted aromatic hydrocarbon group having 6 to 18 carbon atoms, R.sup.2 represents a hydrogen atom or a substituted or unsubstituted aromatic hydrocarbon group having 6 to 18 carbon atoms, R.sup.3 represents an alkyl group having 1 to 4 carbon atoms, R.sup.4 represents a substituted or unsubstituted phenyl group or an aliphatic hydrocarbon group containing at least four .pi. electrons, and m and n individually represent integers of from 1 to 4, or salts thereof, and also to compositions containing the same. These compounds have antifungal activities and are useful as drugs and the like.

R,R,S,S-2-nitroimidazole derivatives

Disclosed herein is an antiprotozoal composition containing a 2-nitroimidazole derivative as its active component. This drug is especially useful against Trypanosoma cruzi. Process for the preparation is also disclosed.

Antiprotozoal composition containing a 2-nitroimidazole derivative and

2-nitroimidazole derivative, production thereof, and radiosensitizer

A novel heterocyclic derivative of formula (I): ##STR1## wherein R.sub.1 represents ##STR2## and R.sub.2 represents hydrogen or acyl. When R.sub.2 is acyl, the derivative can be prepared, for example, by the following process: ##STR3## wherein R.sub.4 is acyl and R.sub.1 is ##STR4## The derivative is less toxic and has radiosensitizing activity and antiviral activity even at a low concentration. Radiosensitizing agents and antiviral agents containing the derivative as active component are also disclosed.

Heterocyclic derivatives useful as radiosensitizing agents and antiviral

Heterocyclic derivatives and radiosensitizing agents and antiviral

Composition for dermatological application to be used for freckles, liver-spots, and acnes containing as an active constituent 0.1 to 40 wt % of a dicarboxylic acid ester, having 7 to 13 carbon atoms as activated constituent and represented by the general formula of ##STR1## wherein n=5-11

Method for dermatological application

Growing community of inventors

Yokohama, Japan

Toshimitsu Suzuki