Teikoku Hormone Mfg. Co., Ltd.

Toshimi Seki

Tsutomu Ishimori

Kikuo Yasuda

Kenyu Shibata

Kotaro Gotanda

Nobuyoshi Minami

Katsuhiko Miyasaka

Masafumi Shiraiwa

Takako Sasaki

Tomio Nakao

Akihiro Izumi

Takashi Yamaguchi

Seijiro Honma

Takeshi Masuda

Norio Himori

Rikio Ohuchi

Kohichi Hasumi

Masako Uno

Yoshitaka Tanimoto

Takayuki Takezaki

Hiroshi Ohuyabu

A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an assymmetric carbon atom, or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.

Pyridazinone derivatives

Carbostyril substituted pyridazinones

A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an asymmetric carbon atom, or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.

A pyridazinone derivative represented by the following general formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group, either one of R.sub.2, R.sub.3 and R.sub.4 represents a hydrogen atom and the remaining two of them represent a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and a salt thereof. The compounds are useful as antihypertensive agents.

Antihypertensive pyridazinone aminoisopropanol derivatives

A hydrazinopyridazine compound represented by the formula ##STR1## wherein R.sup.1 represents a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a lower alkyl group which may optionally be substituted by a halogen atom or a hydroxyl, lower alkoxy, lower alkylthio, lower alkanoylamino, allyloxy or tetrahydrofurfuryloxy group, a lower alkoxy group which may optionally be substituted by a 2-furyl, phenyl or lower alkoxy group, a lower alkenyl group, a lower alkenyloxy group, or a lower alkynyl group; R.sup.2 represents a hydrogen atom, a halogen atom, a cyano group, a lower alkyl group which may optionally be substituted by a halogen atom or a lower alkoxy group, a lower alkoxy group, a lower alkenyl group, or a lower alkenyloxy group; R.sup.3, R.sup.4 and R.sup.5, independently from each other, represent a hydrogen atom, a halogen atom, a lower alkyl group which may optionally be substituted by a lower alkoxy group, or a lower alkoxy group; R.sup.6 and R.sup.7, independently from each other, represent a hydrogen atom or a methyl group; Y represents --NH.sub.2, --NH--COOC.sub.2 H.sub.5, or ##STR2## Z represents --O--, --S--, or ##STR3## in which R.sup.8 represents a hydrogen atom or a lower alkyl group; and n is 1 or 2, or its salt; a process for the production the aforesaid compounds; and use of such compounds as antihypertensive agents.

Hydrazinopyridazine compound, process for production thereof, and use

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Kawasaki, Japan

Toshimi Seki