Nippon Gohsei Kagaku Kogyo Kabushiki Kaisha

Toshimi Ogawa

Toshio Yamamoto

Takehiko Kakimoto

Yoshihiro Hibi

The invention provides a method of purifying 2-alkyl-4-halo-5-formylimidazoles, which comprises dissolving an 2-alkyl-4-halo-5-formylimidazole in an aqueous solution of a sulfonating agent, adjusting the solution to pH 1-6, and removing the impurity 2-alkyl-4,5-dihaloimidazole by filtration or extraction.

Method for purification of 2-alkyl-4-halo-5-formylimidazoles

This invention provides a process for producing 2-alkyl-4-halo-5-formylimidazoles which includes halogenating 2-alkyl-5-formylimidazoles with a N-halosuccinimides in the presence of dioxane or mixture of dioxane and ethylene glycol monomethylether as solvent and in the presence of alkali metal hydrogen carbonate as catalyst, which are readily available, with good yield.

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Ogaki, Japan

Toshimi Ogawa