Kowa Company Limited

Toshimi Mizoguchi

Toshihito Mori

Akio Iwasaki

Masahito Nakayama

Takeo Deushi

Kazuhiro Kamiya

Hisakatsu Ito

Shigeru Kimura

Sohei Tanabe

Takeshi Oda

Takafumi Kunieda

Hisakatsu Itoh

Akira Murakami

Masao Okuchi

Masahiro Tamura

Seiichi Sato

Masao Ohkuchi

Isamu Watanabe

Tomoyuki Koshi

Kyoko Yasuoka

Junko Totsuka

Natsuyo Kumai

Masahoto Nakayama

The present invention is directed to a compound represented by formula (1): (wherein Rrepresents an alkyl group which may have a substituent or an alkenyl group which may have a substituent; and each of Rand Rrepresents a hydrogen atom, an alkyl group, a hydroxyalkyl group, a dihydroxyalkyl group, or an alkynyl group, or Rand Rform, together with the nitrogen atom adjacent thereto, a nitrogen-containing saturated heterocyclic group which may have a substituent) and a drug composition containing the compound. The compound exhibits tumor necrosis factor (TNF-&#x3b1;) production inhibitory effect and improved absorption upon oral administration.

Benzofuran derivative

A novel antibiotic designated as KA-6643 and having the formula, ##STR1## wherein R is hydrogen or --SO.sub.3 H.

.beta.-Lactam antibiotics

A-KA-6643-series antibiotic comprising at least one substance represented by any of the following formulae, or a salt or ester thereof: ##STR1## is effectively useful as an antibacterial and .beta.-lactamase inhibiting agent.

KA-6643-Series antibiotics, process for producing same and medical

An antibiotic KA-6643-A or a salt thereof having the formula: ##STR1## is produced by a process comprising the step of hydrolyzing an antibiotic KA-6643-B of the formula: ##STR2##

Process for producing an antibiotic

Novel antibiotics of the following structure ##STR1## wherein R represents a moiety selected from the group consisting of hydrogen, --COCH.sub.2 NH.sub.2, --COCH.sub.2 NHCONH.sub.2 and --COCH.sub.2 NHCHO; process for preparation thereof; and biologically pure culture for use therein.

Biologically pure culture

An antibiotic substance KA-7038 selected from the group consisting of the compounds having formulae I to VII described in claim 1, mixtures thereof and acid addition salts thereof; an antibiotic composition composed of (i) antibiotically effective amount of aforesaid antibiotic substance KA-7038, and (ii) a pharmaceutically acceptable diluent or carrier. The antibiotic substance KA-7038 can be produced by cultivating an antibiotic substance KA-7038-producing strain belonging to genus Streptomyces, for example Streptomyces sp. KC-7038, and isolating the antibiotic substance KA-7038 from the culture broth.

Process for preparation of antibiotics and biologically pure culture for

Novel antibiotics, process for preparation thereof and biologically pure

Antibiotic KA-7038 and compositions containing same

Antibiotics of the KA-6606 series and pharmaceutical compositions thereof

Growing community of inventors

Higashimurayama, Japan

Toshimi Mizoguchi