Nec Corporation

Ykc Corporation

Toshimasa Yamazaki

Tomoharu Kiyuna

Akihisa Kenmochi

Kenichi Kamijyo

Koichi Watanabe

Minoru Asogawa

Kenichi Kamijo

Kenji Miyazaki

Akira Saitou

Naoyuki Takahashi

Akira Tsugita

Takuji Nabetani

Shinichi Fukuzumi

Jiro Shimada

Tetsuji Tanigawa

Kenichiro Tsuda

Bob W Van Dijk

A proteome analysis method includes using a tandem type mass spectrometer to calculate bond dissociation energy by using molecular simulation, using the bond dissociation energy to obtain prediction information including a cleavage pattern of a peptide and/or peak positions in a mass spectrum and/or the intensity ratio of the mass spectrum, and identifying a protein by using the prediction information and experiment information.

Proteome analysis method and proteome analysis system

The present invention provides a method for analyzing the C-terminal amino acid sequence of a peptide by applying reaction technique for successively releasing the C-terminal amino acids therefrom, which method can suppress, when releasing the C-terminal amino acids of the peptide in sequence, such as an undesirable side reaction as cleavage of peptide bond in the intermediate position of the peptide, and allows to carry out the chemical treatment thereof under widely applicable conditions. In the method according to the present invention, an alkanoic acid anhydride and a perfluoroalkanoic acid both of vapor phase, which are supplied from a mixture containing an alkanoic acid anhydride with a small amount of a perfluoroalkanoic acid added thereto, are allowed to act on a dry sample of the peptide to be examined in a dry atmosphere at a temperature chosen in a range of 15 to 60&#xb0; C.; whereby the release of the C-terminal amino acid is resulted from successive formation of a 5-oxazolone structure being followed by cleavage of the 5-oxazolone ring; and then the C-terminal amino acids sequence is identified by analysis based on the decrease in molecular weight in a series of the reaction products obtained.

Method of analyzing peptide for determining C-terminal amino acid sequence

A balun in which the phase shift may be reduced significantly is disclosed. The balun has three lines, i.e. a first line b, a second line a and a third line c, arranged in parallel with the ground surface. The second line a and the third line c are arranged at the same height from the ground surface GC, the longitudinal length of each respective one of the first line b, second line a and third line c are specified to be equal to a quarter (&#xbc;) of the wavelength at the central frequency in the working band, and the capacitance Ca between the second line a and the ground surface GC is specified to be equal to the capacitance Cab between the second line a and the first line b. Furthermore, the distance hbetween the center of each respective one of the second line a and third line c in the height direction and the ground surface GC located closer to each respective one of the second line a and third line c is specified to be longer than the distance hbetween the center of the first line b in the height direction and the center of each respective one of the second line a and third line c in the height direction, or the permittivity of a dielectric Dis specified to be less than that of a dielectric D

Balun

A wavelet conversion means ( ) for subjecting brain wave data in a single trial to wavelet conversion, a wavelet coefficient window means ( ) for extracting a predetermined area by a wavelet coefficient window from a wavelet coefficient surface obtained by the wavelet conversion, and a brain wave data discriminating means ( ) for discriminating brain wave data by judging whether or not the predetermined area is extracted are provided to automate the work to extract distinguishing patterns from individual (in a single trial) brain wave data and to obtain averaging of the brain wave data. By considering whole of wavelet conversion coefficients, averaging and extraction of a vertex latency of distinguishing patterns can be executed without significantly losing the information of original waveform data.

Brain wave data processing device and storage medium

Obtaining fast dipole size estimation with less influence of noise by using a regional dipole model. An artificial neural network section,executes regional dipole size estimation using a neural network having coupling coefficients representing coupling states among as plurality of units and thresholds thereof.

Living body internal active source estimation apparatus

A live body internal condition predicting and expressing system is capable of predicting the internal condition of a live body on the basis of an electromagnetic field distribution at significantly reduced period. The system comprises an electromagnetic field distribution measuring portion, a training data generating portion generating a plurality of training data on the basis of an electromagnetic field distribution derived from a head model data designating a head model and a predetermined dipole parameter and an internal condition category data describing a relationship between the active region of a brain and the internal condition of the live body, an inference portion deriving a numeric value representative of the active region of the brain from the electromagnetic field distribution in the training data with employing a neural network having predetermined coupling coefficients representative of coupling condition between each unit forming each layer and transforming portion transforming the numeric value representative of the active region in the brain output from said inferencing means into an expression indicative of the internal condition of the live body.

System and method for predicting internal condition of live body

An evoked potential measuring apparatus by which an evoked potential which reflects a variation in internal condition of a human being such as a feeling of strain, a feeling of irritation or a feeling of stress can be measured in a high quality with a high degree of reliability. The apparatus comprises a sensory stimulus application section, an evoked potential measurement section for measuring and amplifying an evoked brain potential, an evoked potential recording control section for controlling recording of a brain potential signal, an evoked potential recording section for recording the brain potential signal, an internal condition estimating physiological measure measurement section for measuring a physiological measure, a physiological measure signal recording control section for controlling recording of a physiological measure signal, a physiological measure signal recording section for recording the physiological measure signal, an internal condition estimation section for estimating the internal condition of the subject using the physiological measure signal, an evoked potential adding and averaging section for adding and averaging the brain potential signal in accordance with the internal condition of the subject to obtain an evoked potential, an evoked potential adoption determination section for estimating a quality of the evoked potential to determine whether or not the evoked potential may be adopted, and an evoked potential measurement procedure control section.

Evoked potential measuring apparatus

An equivalent dipole localization system comprising, potential measurement means for simultaneously measuring the potentials on a plurality of electrodes attached in a living body, dipole model calculation means for assuming a electric dipole at a given position in the living body having a character of a medium and calculating positions corresponding to the plurality of electrodes formed by the electric dipole, correlation function calculation means for calculating a spacial correlation function of the potential on each electrode from the measurement of the potential measurement means, maximum likelihood estimated error calculation means for calculating an error between a measured value obtained by the potential measurement means and a calculated value obtained by the dipole model calculation means according to calculated values obtained by the correlation function calculation means, and equivalent electric dipole setting means for setting an equivalent electric dipole by obtaining the location, the vector component and the intensity thereof of electric dipole that can minimize the error obtained by the maximum likelihood estimated error calculation means.

Growing community of inventors

Tokyo, Japan

Toshimasa Yamazaki