Teikoku Seiyaku Co., Ltd.

Ss Pharmaceutical Co., Ltd.

Toshikuni Kawaji

Masahiro Yamaji

Akira Iwasa

Ryoji Konishi

Akihito Oji

Manabu Ishihara

Osami Makaya

An aqueous hot melted type adhesive base material containing 4-biphenylyl acetic acid (BPAA) is provided. The adhesive base material contains constant amounts of BPAA and has good drug releasability, so that bioavailability of the drug is enhanced. An analgesic and anti-inflammatory external plaster containing BPAA is also provided. The plaster is obtained by dissolving BPAA into an aqueous hot melted type adhesive base material comprising as essential components a styrene-isoprene-styrene block copolymer, an adhesive resin, an antioxidant, lanolin, and water.

External plaster containing 4-biphenylacetic acid

An external plaster using an aqueous hot melted type adhesive base material stably containing water-soluble drug having good drug releasability, so that bioavailability of the drug is enhanced, is provided. The aqueous hot melted type adhesive base material used in the external plaster comprising as essential components a styrene-isoprene-styrene block copolymer, an adhesive resin, an antioxidant, lanolin, and water.

Adhesive preparation for external use

The oil patches containing diclofenac sodium which are characterized in that diclofenac sodium, isostearic acid and a fatty acid having 10 to 18 carbon atoms which is liquid at ordinary temperature are combined in an adhesive.

Oily patches for external use containing diclofenac sodium

The present invention provides plasters containing an adhesive base material which comprise , by wt % of the adhesive base material, 15-25 wt % of isosorbide dinitrate, 15-35 wt % of styrene-isoprene-styrene block copolymer, 35-55 wt % of rosin resin, 5-20 wt % of liquid rubber, 0.1-2 wt % of antioxidant, and 0.1-5 wt % of oleic acid for transdermal application. The plasters of the present invention have excellent adhesion and stable releasing of the active ingredient from the adhesive layer after applied to the skin.

Plasters containing isosorbide dinitrate

Patch preparations for percutaneous adsorption with the use of supports showing appropriate strength as a patch support, which are excellent in drug barrier characteristics, compatibility with the skin, ODT effects and handling characteristics and can sustain these specific properties in a stable state over a prolonged period of time, thus ensuring good percutaneous absorption of drugs. In these patch preparation, use is made as the support of polyester film/nonwoven vinylon fabric laminates showing an elongation percentage of at least 5% and a tensile cutting load of at least 0.5 kg/10 mm, when measured by the test method specified in JIS K6732. In particular, the thickness of the polyester film constituting the laminate supports ranges from 1.5 to 6.0 &mgr;m and the unit weight of the nonwoven vinylon fabric ranges from 3 to 12 g/m,.

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Ohkawa-gun, Japan

Toshikuni Kawaji