Toyo Kasei Kogyo Company Limited

Sumitomo Chemical Company, Limited

Toyo Boseki Kabushiki Kaisha

Toshikazu Oga

Ryozo Orita

Toru Kofukuda

Sunao Mitsui

Kiyoto Koguro

Norihito Tokunaga

The present invention provides a process for purifying 2-chloro-5-chloromethyl-1,3-thiazole represented by the formula (I): characterized in that a crude 2-chloro-5-chloromethyl-1,3-thiazole represented by the formula (I) is treated with a lower alcohol before the distillation, and then is distilled. The present purification process is a new one for purifying 2-chloro-5-chloromethyl-1,3-thiazole, suitable for industrial practice.

Process for purification of 2-chloro-5-chloromethyl-1,3-thiazole

The invention is directed to a process for preparing a 5-substituted tetrazole, the process comprising the step of reacting a nitrile with an inorganic azide salt in an aromatic hydrocarbon solvent in the presence of an amine salt. According to the invention, a 5-substituted tetrazole can be produced in a high yield with ease and safety using inexpensive raw materials while the reaction is easily controlled to inhibit a side reaction.

Process for preparation of a 1-(tetrazolylbiphenylmethyl)-imidazole

Process for preparation of 5-  substituted tetrazoles

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Takasago, Japan

Toshikazu Oga